Implementation of a digital Clinical Decision Support System / ICRC Somalia (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/implementation-of-a-digital-clinical-decision-support-system-/-icrc-somalia
of infant and child mortality are illnesses such as pneumonia (21%), diarrhoea (14%), and measles (5%), as well as neonatal deaths (29%). Owing to insecurity and displacement, over half a million young [...] risk of contracting diseases. To improve the quality of care for children between 2 and 59 months (< 5 years) old in the South-Central Somali region, the International Committee of the Red Cross (ICRC) and [...] intervention, which has the potential to significantly improve the quality of...
Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
Immunization with PfSPZ Vaccine induced IgG and IgM isotypes specific for the Merozoite surface protein 5 (PfMSP 5) and the circumsporozoite protein (PfCSP) regardless of HIV infection status. Interestingly, volunteers [...] protection since no difference was observed between CHMI protected and non-protected volunteers. Manuscript 5: HIV-1 positive and HIV-1 negative Tanzanian adults undergoing whole irradiation attenuated Plasmodium [...] vaccination mount antibody responses targeting the...
Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
Immunization with PfSPZ Vaccine induced IgG and IgM isotypes specific for the Merozoite surface protein 5 (PfMSP 5) and the circumsporozoite protein (PfCSP) regardless of HIV infection status. Interestingly, volunteers [...] protection since no difference was observed between CHMI protected and non-protected volunteers. Manuscript 5: HIV-1 positive and HIV-1 negative Tanzanian adults undergoing whole irradiation attenuated Plasmodium [...] vaccination mount antibody responses targeting the...
Rating early child development outcome measurement tools for routine health programme use (Publications)
tions, Assessment, Development and Evaluations. RESULTS: 61 tools were initially identified, 8% (n=5) population-level and 92% (n=56) individual-level screening or ability tests. Of these, 27 tools covering
Design, synthesis, and biological evaluation of new 1-(Aryl-1<em>H</em>-pyrrolyl)(phenyl)methyl-1<em>H</em>-imidazole derivatives as antiprotozoal... (Publications)
provided against a number of different protozoa. The mechanism of action for the most potent derivatives (5i, 6a-c, 8b) was assessed by a target-based assays using recombinant T. cruzi CYP51. Bioavailability
Discovery of an orally active nitrothiophene-based antitrypanosomal agent (Publications)
trypanosomes and are metabolically stable. One of the compounds, (E)-N-(4-(methylamino)-4-oxobut-2-en-1-yl)-5-nitrothiophene-2-carboxamide (10), selectively inhibited the growth of T. b. brucei, T. b. gambiense
Substituted 2-phenyl-imidazopyridines: a new class of drug leads for human African trypanosomiasis (Publications)
exposure in mice. Compound 87 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg. Given its potent anti-parasitic properties and its ease of synthesis, compound 87 represents
Antiprotozoal screening of 60 south African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II (Publications)
from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC50 values of 0.9, 1.5, and 0.23 microM, respectively
Preparedness of anesthesiologists working in humanitarian disasters (Publications)
should improve preparedness for anesthesia personnel. (Disaster Med Public Health Preparedness. 2013;0;1-5).
Arylmethylamino steroids as antiparasitic agents (Publications)
intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC50 1-5 nM) as well as against gametocytes. In P. berghei-infected mice, oral administration of 1o drastically