The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks <em>Plasmodium falciparum</em> transmission to Anopheles... (Publications)
and late development of Plasmodium falciparum gametocytes in vitro in a dose dependent fashion over a 5-500 nM range. In addition, using the standard membrane feeding assay, NITD609 was also found to be a
Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium <em>Lyngbya majuscula</em> (Publications)
potent cytotoxic activity against P388 murine leukemia cell lines, with IC(50) values of 6.4 and 20.5 nM, respectively. Furthermore, these cyanobacterial compounds exhibited moderate antiswarming activities
Treatment with coartem (artemether-lumefantrine) in Papua New Guinea (Publications)
(artemether-lumefantrine) to be highly effective against Plasmodium falciparum in children less than 5 years of age in Papua New Guinea (PNG). In contrast, we have observed high levels of treatment failures
Compliance with focused antenatal care services: do health workers in rural Burkina Faso, Uganda and Tanzania perform all ANC procedures? (Publications)
three African countries. This descriptive observational study took place in HF in Nouna, Burkina Faso (5), Iganga, Uganda (6) and Rufiji, Tanzania (7). In total, 788 ANC sessions and service provisions were
Prevalence and risk factors for carriage of multi-drug resistant <em>Staphylococci</em> in healthy cats and dogs (Publications)
with an increased risk of colonisation by multi-drug resistant Staphylococci (OR = 2.4, 95% CI: 1.1 5.2, p value LRT = 0.04). When identifying efficient control strategies against antibiotic resistance
Trypanocidal activity of diarylheptanoids from <em>Schrankia leptocarpa</em> DC (Publications)
leptocarpa DC. (Mimosaceae) led to the isolation of two diarylheptanoids (1-2), three phenolic acid (3-5), one p-coumaric acid derivate (6) and three flavonoids (7-9). The structures of the isolated compounds
Evaluating decontamination protocols for the isolation of <em>Mycobacterium ulcerans</em> from swabs (Publications)
potential decontamination agents for the isolation of M. ulcerans from swabs. RESULTS: Povidone iodine at 0.5 and 1% exhibited the lowest contamination and recovery rate for microbial contaminants and M. ulcerans
Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting... (Publications)
evaluated and the respective selectivity indices (SI) were calculated. We found that benzyl naphthoquinone 5c was the most active and selective molecule against T. brucei rhodesiense (IC50 = 0.08 muM, SI = 275)
Benefit-cost analysis of coordinated strategies for control of rabies in Africa (Publications)
countries and PEP would lead to the elimination of dog rabies in Africa with total welfare gains of USD 9.5 billion (95% CI: 8.1 - 11.4 billion) between 2024 and 2054 (30 years). Coordinated disease control between
Impact of COVID-19 on the utilization of HIV testing and linkage services in Sierra Leone: experience from three public health facilities in Freetown (Publications)
compared with pre-pandemic HTS (2019). Of the 8538 people tested for HIV in the three facilities, 4929 (57.5%) visited CH. Only 2249 people were tested for HIV in 2020 compared to 3825 in 2019 (difference: - 41