Combining PCR with microscopy to reduce costs of laboratory diagnosis of Buruli ulcer (Publications)
were negative in microscopic analysis. This stepwise approach reduced unit cost by more than 50% to $5.41, and the total costs were reduced from $917 to $433
Genotyping of <em>Cryptosporidium </em>spp. isolated from human stool samples in Switzerland (Publications)
strains from calves, one of the isolates showed a full sequence identity and the other a similarity of 97.5%. The fact that only bovine genotypes were detected suggests, that cryptosporidiosis must primarily
Antimalarial beta-carbolines from the New Zealand ascidian<em> Pseudodistoma opacum</em> (Publications)
activity toward a chloroquine-resistant strain of Plasmodium falciparum, with an IC(50) range of 2.5-14 muM. The biosynthesis of 1-4 is proposed to proceed via a Pictet-Spengler condensation of 6-brom
Prodrugs of reverse fosmidomycin analogues (Publications)
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium falciparum. The drug has been used
RFX transcription factors are essential for hearing in mice (Publications)
essential and evolutionarily conserved regulators of the HC-specific transcriptomes, and detect Rfx1,2,3,5 and 7 in the developing HCs. To understand the role of RFX in hearing, we generate Rfx1/3 conditional
Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015) (Publications)
Advisory Committee to the World Health Organization held its seventh meeting in Geneva, Switzerland from 5 to 7 March 2015. This article provides a summary of the discussions, conclusions and meeting recommendations
Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids (Publications)
pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and jasmolin I (5)] from this extract. These were tested together with 15 synthetic pyrethroids for their activity against
Skin lesions, malaise, and heart failure in a renal transplant recipient (Publications)
an endemic area, but had an extensive travel history in South America. The last visit was more than 5 years before transplantation. In non-endemic countries (United States, Europe), reactivation after
Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude (Publications)
pulmonary artery pressure in children was greater than that in adults at day 1 of high altitude (15.5+/-9.1 versus 7.9+/-6.4 mmHg), but returned to adult levels on day 2. The increase in pulmonary artery
Efficacy of artesunate and artemether against <em>Clonorchis sinensis</em> in rabbits (Publications)
metacercariae. At day 28 postinfection, the rabbits were administered oral artesunate at doses of 7.5-120 mg/kg and oral artemether of 15-120 mg/kg. Two groups of rabbits were treated with single oral