Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids (Publications)
pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and jasmolin I (5)] from this extract. These were tested together with 15 synthetic pyrethroids for their activity against
Antimalarial beta-carbolines from the New Zealand ascidian<em> Pseudodistoma opacum</em> (Publications)
activity toward a chloroquine-resistant strain of Plasmodium falciparum, with an IC(50) range of 2.5-14 muM. The biosynthesis of 1-4 is proposed to proceed via a Pictet-Spengler condensation of 6-brom
Genotyping of <em>Cryptosporidium </em>spp. isolated from human stool samples in Switzerland (Publications)
strains from calves, one of the isolates showed a full sequence identity and the other a similarity of 97.5%. The fact that only bovine genotypes were detected suggests, that cryptosporidiosis must primarily
Compliance with focused antenatal care services: do health workers in rural Burkina Faso, Uganda and Tanzania perform all ANC procedures? (Publications)
three African countries. This descriptive observational study took place in HF in Nouna, Burkina Faso (5), Iganga, Uganda (6) and Rufiji, Tanzania (7). In total, 788 ANC sessions and service provisions were
Treatment with coartem (artemether-lumefantrine) in Papua New Guinea (Publications)
(artemether-lumefantrine) to be highly effective against Plasmodium falciparum in children less than 5 years of age in Papua New Guinea (PNG). In contrast, we have observed high levels of treatment failures
Skin lesions, malaise, and heart failure in a renal transplant recipient (Publications)
an endemic area, but had an extensive travel history in South America. The last visit was more than 5 years before transplantation. In non-endemic countries (United States, Europe), reactivation after
Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude (Publications)
pulmonary artery pressure in children was greater than that in adults at day 1 of high altitude (15.5+/-9.1 versus 7.9+/-6.4 mmHg), but returned to adult levels on day 2. The increase in pulmonary artery
Efficacy of artesunate and artemether against <em>Clonorchis sinensis</em> in rabbits (Publications)
metacercariae. At day 28 postinfection, the rabbits were administered oral artesunate at doses of 7.5-120 mg/kg and oral artemether of 15-120 mg/kg. Two groups of rabbits were treated with single oral
Combining PCR with microscopy to reduce costs of laboratory diagnosis of Buruli ulcer (Publications)
were negative in microscopic analysis. This stepwise approach reduced unit cost by more than 50% to $5.41, and the total costs were reduced from $917 to $433
Prodrugs of reverse fosmidomycin analogues (Publications)
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium falciparum. The drug has been used