Antimalarial beta-carbolines from the New Zealand ascidian<em> Pseudodistoma opacum</em> (Publications)
activity toward a chloroquine-resistant strain of Plasmodium falciparum, with an IC(50) range of 2.5-14 muM. The biosynthesis of 1-4 is proposed to proceed via a Pictet-Spengler condensation of 6-brom
Compliance with focused antenatal care services: do health workers in rural Burkina Faso, Uganda and Tanzania perform all ANC procedures? (Publications)
three African countries. This descriptive observational study took place in HF in Nouna, Burkina Faso (5), Iganga, Uganda (6) and Rufiji, Tanzania (7). In total, 788 ANC sessions and service provisions were
Treatment with coartem (artemether-lumefantrine) in Papua New Guinea (Publications)
(artemether-lumefantrine) to be highly effective against Plasmodium falciparum in children less than 5 years of age in Papua New Guinea (PNG). In contrast, we have observed high levels of treatment failures
Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids (Publications)
pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and jasmolin I (5)] from this extract. These were tested together with 15 synthetic pyrethroids for their activity against
Genotyping of <em>Cryptosporidium </em>spp. isolated from human stool samples in Switzerland (Publications)
strains from calves, one of the isolates showed a full sequence identity and the other a similarity of 97.5%. The fact that only bovine genotypes were detected suggests, that cryptosporidiosis must primarily
Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium <em>Lyngbya majuscula</em> (Publications)
potent cytotoxic activity against P388 murine leukemia cell lines, with IC(50) values of 6.4 and 20.5 nM, respectively. Furthermore, these cyanobacterial compounds exhibited moderate antiswarming activities
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks <em>Plasmodium falciparum</em> transmission to Anopheles... (Publications)
and late development of Plasmodium falciparum gametocytes in vitro in a dose dependent fashion over a 5-500 nM range. In addition, using the standard membrane feeding assay, NITD609 was also found to be a
Trypanocidal activity of diarylheptanoids from <em>Schrankia leptocarpa</em> DC (Publications)
leptocarpa DC. (Mimosaceae) led to the isolation of two diarylheptanoids (1-2), three phenolic acid (3-5), one p-coumaric acid derivate (6) and three flavonoids (7-9). The structures of the isolated compounds
Evaluating decontamination protocols for the isolation of <em>Mycobacterium ulcerans</em> from swabs (Publications)
potential decontamination agents for the isolation of M. ulcerans from swabs. RESULTS: Povidone iodine at 0.5 and 1% exhibited the lowest contamination and recovery rate for microbial contaminants and M. ulcerans
Impact of COVID-19 on the utilization of HIV testing and linkage services in Sierra Leone: experience from three public health facilities in Freetown (Publications)
compared with pre-pandemic HTS (2019). Of the 8538 people tested for HIV in the three facilities, 4929 (57.5%) visited CH. Only 2249 people were tested for HIV in 2020 compared to 3825 in 2019 (difference: - 41