<em>Plasmodium falciparum</em> centromeres display a unique epigenetic makeup and cluster prior to and during schizogony (Publications)
composition remained undefined. Here, we reveal that the centromeric histone variant PfCENH3 occupies a 4-4.5kb region on each P. falciparum chromosome, which is devoid of pericentric heterochromatin but harbors
Antitrypanosomal and antiplasmodial activity of medicinal plants from Côte d' Ivoire (Publications)
(Annonaceae) and Trichilia emetica (Meliaceae) were the most promising ones. Their IC50 values were 0.5 and 0.04 microg/ml, respectively, and the selectivity index 616 and 209, respectively. This is the first
Building community health resilience and alleviating poverty through multi-sectoral cooperation for elimination of schistosomiasis in Cambodia and Lao... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/building-community-health-resilience-and-alleviating-poverty-through-multi-sectoral-cooperation-for-elimination-of-schistosomiasis-in-cambodia-and-lao-peoples-democratic-republic
and operational research are designed to measure impacts and generate evidence of success; and target 5: All activities under the Project are implemented according to the proposal. Key activities proposed
New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities (Publications)
efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3-(trifluoromethyl)benzamide possessed good physicochemical properties and showed high
Genomic analyses of <em>Mycobacterium tuberculosis</em> from human lung resections reveal a high frequency of polyclonal infections (Publications)
the detection of multiple strains (40% of surgery cases) as opposed to just using a sputum sample (0-5% in the general population). We show that polyclonal infections often involve genetically distant strains
Quantitative assessment of eosinophiluria in <em>Schistosoma haematobium</em> infections: a new marker of infection and bladder morbidity (Publications)
resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP > or =5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a
Diversity of human intestinal helminthiasis in Lao PDR (Publications)
trematodes included Phaneropsolus bonnei (22.7%), Prosthodendrium molenkampi (14.4%), Haplorchis pumilio (5.2%), Haplorchis yokogawai (3.1%) and Echinochasmus japonicus (3.1%). Co-infection with O. viverrini
Jozimine A2: the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity (Publications)
prepared by semi-synthesis from the co-occurring (and likewise synthetically available) dioncophylline A (5), along with its atropo-diastereomer, 3'-epi-2.
Treatment of cutaneous leishmaniasis among travellers (Publications)
Leishmaniasis is endemic in 88 countries on five continents. There are 1-1.5 million cases of cutaneous leishmaniasis reported yearly worldwide. There has been a sharp increase in recorded cases over the
Antitrypanosomal and antiplasmodial activity of medicinal plants from Côte d' Ivoire (Publications)
(Annonaceae) and Trichilia emetica (Meliaceae) were the most promising ones. Their IC50 values were 0.5 and 0.04 microg/ml, respectively, and the selectivity index 616 and 209, respectively. This is the first