Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule (Publications)
covalent inhibition is not preceded by the formation of a strong non-covalent complex. However, an up to 5-fold difference in inactivation rates among homologs hinted at structural or electrostatic differences
Integrated Quality Management System (IQMS): ein Modell zur Förderung der Qualität der reproduktiven Gesundheitsversorgung in Kenia (Publications)
Kenyan experts. RESULTS: 260 indicators were rated as relevant and assigned to 29 quality dimensions and 5 domains. The implementation of IQMS in ten facilities showed that IQMS is a feasible model for assessing
Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach (Publications)
and current asthma prevalence.PM10 or NO2 higher by 10 microg.m-3 was associated with 12.8% (95% CI 9.5-16.3%) and 1.9% (95% CI 1.1-2.8%) higher lifetime asthma prevalence, respectively, independent of c
Comparison of <em>Leishmania</em> typing results obtained from 16 European clinical laboratories in 2014 (Publications)
species were reported. The overall error rate of strains placed in the wrong complex or species was 8.5%. Various reasons for incorrect typing were identified. The study shows there is considerable room for
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis (Publications)
given orally at doses of 25-50 mg/kg for 4 days for the acute infection, and 50-100 mg/kg (bid) for 5 days in the chronic model. While both compounds are bacterial mutagens, activity is lost in strains
Recent investigations of artemether, a novel agent for the prevention of <em>Schistosomiasis japonica, mansoni </em>and <em>haematobia</em> (Publications)
indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Randomized controlled clinical trials confirmed that artemether, orally administered at a dose
Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved <em>Plasmodium falciparum</em>... (Publications)
PfSPZ groups geometric mean days from injection to Pf positivity by thick blood film was 15.4 versus 13.5 (P = 0.023). Alpha-thalassemia heterozygosity had no apparent effect on infectivity. PfSPZ Challenge
Determination of methoxyphenols in ambient atmospheric particulate matter: tracers for wood combustion (Publications)
analyte recoveries in each sample. Analytical figures of merit for the assay, as applied to ambient PM2.5 and PM10 samples are as follows: recovery = 63-100%; precision = 2-6%; analytical limit of detection
Combining synthetic human odours and low-cost electrocuting grids to attract and kill outdoor-biting mosquitoes: field and semi-field evaluation of an... (Publications)
susceptibility to pyrethroids. MLBs with three grids were also tested in a large semi-field cage (9.6x9.6x4.5m), to assess effects on biting-densities of laboratory-reared Anopheles arabiensis on volunteers sitting
Dose-response relationships and tegumental surface alterations in <em>Opisthorchis viverrini</em> following treatment with mefloquine in vivo and in... (Publications)
vitro incubation. A single oral dose of 300-mg/kg mefloquine resulted in worm burden reductions of 88.5% (juvenile infection) and 96.0% (adult infections), respectively. Incubation with 10 and 100 microg/ml