Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
parasites, with limited proteolysis also enabling estimation of the binding site on PfA-M1 to within ~5 Å of that determined by X-ray crystallography. Finally, functional investigation by untargeted metabolomics
Climate change, malaria and neglected tropical diseases: a scoping review (Publications)
relatively understudied. Mitigation was considered in 174 papers (34%) and adaption strategies in 24 (5%). Amplitude and direction of effects of climate change on malaria and NTDs are likely to vary by disease
Multiplex PCR for bacterial, viral and protozoal pathogens in persistent diarrhoea or persistent abdominal pain in Côte d'Ivoire, Mali and Nepal (Publications)
Campylobacter spp. (3.9-35.3%). Giardia intestinalis was the predominant intestinal protozoon (2.9-20.5%), and adenovirus 40/41 was the most frequently observed viral pathogen (6.3-25.1%). Significantly different
Socio-demographic determinants of low birth weight: evidence from the Kassena-Nankana districts of the Upper East Region of Ghana (Publications)
prevalence of low birth weight was 13.8% 95%CI [13.10, 14.6] and more in female babies than in males (15.5% vs 12.2%; p
The burden of gastroenteritis in Switzerland (BUGS) study: a research proposal for a 1-year, prospective cohort study (Publications)
usually self-limiting, but common disease worldwide. In Europe, incidence estimates range from 0.3-1.5 AG episodes/person-year. For Switzerland, available information on AG is restricted to notifiable foodborne
Somatic mutation footprinting reveals a unique tetra-nucleotide signature associated with intron-exon boundaries in lung cancer (Publications)
level and intron-exon junctions. Intriguingly, its distribution across the genome is biased towards 5' splice junctions, suggesting a novel mechanism of mutation.
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (Publications)
structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants
Air quality in Tehran, Iran: evaluating acute health effects and modeling the long-term spatial variability (Publications)
polluted area. Even so, more than 80% of Tehran had benzene concentrations above air quality standard of 5 µg/m3 set by European Union and Iranian Government. The thesis also included a systematic review of
A controlled trial to reduce the risk of human Nipah virus exposure in Bangladesh (Publications)
consuming raw sap from a protected source than those with no exposure (25 vs. 15%, OR 2.0, 95% CI 1.5-2.6, P < 0.001). While the intervention increased knowledge in both intervention areas, the "only safe
Marginal bone loss 1 year after implantation: a systematic review for fixed and removable restorations (Publications)
selected. Related to fixed restorations, the lowest MBL was 0.05+/-0.67 mm and the highest 1.37+/-0.5 mm. The MBL for removable restorations ranged from 0.13+/-0.35 mm to 1.03+/-0.65 mm. Three studies analyzed
