Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence... (Publications)
LiN[Si(CH(3))(3)](2) or by Pinner methodology. Specifically, we have prepared new series of 2,6- and 2,5-diaryl indoles (6a,b, 12 and 17a-d) and the related benzimidazoles (24, 30 and 35). The new compounds
Extended-spectrum beta-lactamase-producing <em>Enterobacteriaceae</em> in healthy companion animals living in nursing homes and in the community (Publications)
ts of resistance. RESULTS: The overall prevalence of ESBL isolates, adjusted for clustering, was 2.5% (95% confidence interval: 1.3-4.6). Pets that received an antibiotic treatment in the 3 months prior
Outcome of radioiodine therapy without, on or 3 days off carbimazole: a prospective interventional three-group comparison (Publications)
completed follow-up (toxic nodular goitre, n=117; Graves' disease, n=90). The overall success rate was 71.5%. Patients without and 3 days off carbimazole had similar biochemical (81.4% and 83.3%, respectively;
Random demographic household surveys in highly mobile pastoral communities in Chad (Publications)
of husbands in typically patriarchal societies. RELEVANT CHANGES: Due to their high mobility, only 5% (56/1081) of registered women were encountered twice. Therefore, it was not possible to establish a
Animal presence modulates frontal brain activity of patients in a minimally conscious state: a pilot study (Publications)
session had five phases: (1) baseline, (2) watching animal, (3) passive contact, (4) active contact, (5) neutral. Data were descriptively analysed. All participants showed the largest hemodynamic response
Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a (Publications)
X-ray structural data to inform optimization and then applied a scaffold-hop strategy to identify the 5-carboxamide thiazole hydrazone scaffold (43) with potent sBCL-2 activity (IC(50) 30 nM). Human BCL-XL
Western European land use regression incorporating satellite- and ground-based measurements of NO2 and PM10 (Publications)
10km, altitude, and distance to sea. We explore models with and without satellite-based NO2 and PM2.5 as predictor variables and we compare two available land cover datasets (global; European). Model p
Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA) (Publications)
its maximal value per mumol methacholine. Bronchial hyper-reactivity prevalence fell from 14.3% to 12.5% during follow-up. Baseline age was non-linearly associated to change in reactivity slope: participants
Sex-specific associations of cardiovascular risk factors with carotid stiffness - results from the SAPALDIA cohort study (Publications)
per 1SD of the risk factor on an inverted scale) and significant adverse risk factors were BMI (-0.5; 4.7%), systolic (-1.23; 4.7%) and diastolic blood pressure (1.4; 4.4%), heart rate (2.7; 7.9%), C-reactive
Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels (Publications)
individuals of the SAPALDIA cohort. Five common SNPs, defined by showing minor allele frequencies (MAFs) > 5%, reached genome-wide significance, all located in the SERPINA gene cluster at 14q32.13. The top-ranking