Land use regression models for crustal and traffic-related PM2.5 constituents in four areas of the SAPALDIA study (Publications)
particulate matter (PM2.5), but there is still limited knowledge regarding the causal relationship between specific sources of PM2.5 and such health effects. The spatial variability of PM2.5 constituents and [...] (SAPALDIA). Reflectance analysis and energy dispersive X-ray fluorescence (XRF) were performed on PM2.5 filter samples to estimate light absorbance and trace element concentrations, respectively. Three air
Antileukemic ancistrobenomine B and related 5,1′-coupled naphthylisoquinoline alkaloids from the Chinese liana <em>Ancistrocladus tectorius</em> (Publications)
predominance of 5,1'-coupled naphthylisoquinoline alkaloids. About 20 alkaloids of this coupling type have so far been discovered in this plant species. Here, we report on the isolation of four new 5,1'-linked [...] naphthylisoquinolines from the twigs and stems of A. tectorius. Two of them, the ancistrobenomines B (5) and C (6), belong to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion [...] from one single naphthalene-devoid 3-hydroxymethyleneisoquinoline from...
Comparison of next-generation portable pollution monitors to measure exposure to PM2.5 from household air pollution in Puno, Peru (Publications)
exposure to PM2.5 is critical for understanding intervention effectiveness and exposure-response relationships in household air pollution studies. In this pilot study, we compared PM2.5 concentrations obtained
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity (Publications)
existing therapies are partially ineffective and cause serious adverse effects. Formation of the PEX14-PEX5 complex is essential for protein import into the parasites' glycosomes. This transport is critical for [...] on of glycosomal enzymes, with fatal consequences for the parasite. Hence, inhibiting the PEX14-PEX5 protein-protein interaction (PPI) is an attractive way to affect multiple metabolic pathways. Herein [...] computational screening and optimization to develop the first line of...
In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative... (Publications)
the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gram-negative bacteria. Therefore, C3 and C5 inhibition increases the risk [...] against complement components other than C3 and C5 may carry a reduced risk of infection, we compared the effect of inhibitors targeting the terminal pathway (C5), the central complement component C3, the [...] H-binding protein (fHbp). SBA triggered by these cell surface...
The air and viruses we breathe: assessing the effect the PM2.5 air pollutant has on the burden of COVID-19 (Publications)
burden of respiratory viral diseases. We assessed the effect of increasing exposure to PM2.5 (particulate matter ≤ 2.5 microns in diameter) on SARS-CoV-2 susceptibility or COVID-19 severity and projected the [...] population show that if exposure affects severity, then hospital admissions are projected to increase by 5–10% for a one-unit exposure increase. However, if exposure affects susceptibility, then infections would [...] respond to changing air pollution levels. It is also important to...
Macrophage susceptibility to infection by Ghanaian <em>Mycobacterium tuberculosis</em> complex lineages 4 and 5 varies with self-reported ethnicity (Publications)
BACKGROUND: The epidemiology of Mycobacterium tuberculosis complex (MTBC) lineage 5 (L5) infections in Ghana revealed a significantly increased prevalence in Ewes compared to other self-reported ethnic [...] 001), translating into a higher bacillary load on day 7 (p < 0.001) compared to L5, despite the higher replication rate of L5 in Ewe MDMs (fold change: 1.4 vs. 1.2, p = 0.03) among the controls. On the contrary [...] phagocytic uptake of L5 (p < 0.001) compared to L4, also translating into a...
Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 inflammasome (Publications)
conditions. To uncover the possible therapy for PM(2.5) related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM(2.5) induced lung injury in mice by utilizing the survival [...] findings strongly indicated Sal as an effective precaution against PM(2.5) induced lung injury. Pre-administration of Sal before PM(2.5) treatment reduced the mortality within 120 h and alleviated inflammatory [...] PM(2.5) treatment via regulating Bax/Bcl-2/caspase-3 and...
Bayesian geostatistical modelling of PM10 and PM2.5 surface level concentrations in Europe using high-resolution satellite-derived products (Publications)
pollutants and remotely sensed predictors were developed to estimate yearly averages of both, fine (PM2.5) and coarse (PM10) surface PM concentrations, at 1km(2) spatial resolution over 46 European countries [...] predictive ability of the frequently employed land-use regression. The resulting estimates of PM10 and PM2.5, which represent the main air quality indicators for the urban Sustainable Development Goal, indicate