Evaluation of <em>in vitro</em> antiprotozoal activity of <em>Ajuga laxmannii </em>and its secondary metabolites (Publications)
three o-coumaric acid derivatives cis-melilotoside (3), trans-melilotoside (4) and dihydromelilotoside (5), two phenylethanoid glycosides verbascoside (6) and galactosylmartynoside (7) and a flavone-C-glycoside
Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania (Publications)
III/IV HIV disease and median CD4 count was 179 cells/muL. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8%-8.9%). There was no significant predictor of anti-HDV positivity. HDV
Outcomes of antiretroviral treatment programmes in rural Lesotho: health centres and hospitals compared (Publications)
catchment area and type of ART. All analyses were stratified by gender. RESULTS: Of 3747 patients, 2042 (54.5%) started ART at HCs. Both women and men at hospitals had more advanced clinical and immunological stages
Approved oncology drugs lack <em>in vivo</em> activity against <em>Trichuris muris</em> despite <em>in vitro</em> activity (Publications)
adult worm stage (> 80 % drug effect at 50 muM), of which six revealed IC50 values between 1.8 and 5.0 muM. Except for tamoxifen citrate, all in vitro active drugs were protein kinase inhibitors. None
Sleep disturbance from road traffic, railways, airplanes and from total environmental noise levels in Montreal (Publications)
was 12.4%. The proportion of those affected by road traffic, airplane and railway noise was 4.2%, 1.5% and 1.1%, respectively. We observed an increased prevalence in sleep disturbance for those exposed
Insecticide resistance and its association with target-site mutations in natural populations of <em>Anopheles gambiae</em> from eastern Uganda (Publications)
Survival rates to DDT were as high as 85.4%, alongside significant resistance levels to permethrin (38.5%), reduced susceptibility to deltamethrin, but full susceptibility to bendiocarb and malathion. Using
Risk factors and spatial patterns of hookworm infection among schoolchildren in a rural area of western Côte d'Ivoire (Publications)
hookworm infection prevalence, based on the pooled microscopic diagnoses, was 43.3% and ranged from 5.4 to 79.1% in the schools surveyed. Bivariate analyses showed that sex, age, socio-economic status,
Activity of praziquantel enantiomers and main metabolites against <em>Schistosoma mansoni</em> (Publications)
e. the migration of the worms to the liver) produced by each PZQ enantiomer in mice. IC50s of 0.02, 5.85, 4.08 and 2.42 mug/mL on adult S. mansoni were determined in vitro for R-PZQ, S-PZQ, R-trans and
Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA (Publications)
cycle progression. Intriguingly, we found that PfTRZ also binds to and regulates the expression of 5S rDNA genes. Combined with detailed phylogenetic analyses, our findings identified PfTRZ as a remote
Association between serum vitamin D, retinol and zinc status, and acute respiratory infections in underweight and normal-weight children aged 6-24... (Publications)
children with zinc insufficiency and those that were serum retinol deficient had 1.2 (95% CI 1.0-1.5) times higher risk of URI and 1.9 (95% CI 1.4-2.6) times higher risk of ALRI, respectively. Thus, our