Outcomes of antiretroviral treatment programmes in rural Lesotho: health centres and hospitals compared (Publications)
catchment area and type of ART. All analyses were stratified by gender. RESULTS: Of 3747 patients, 2042 (54.5%) started ART at HCs. Both women and men at hospitals had more advanced clinical and immunological stages
Association between serum vitamin D, retinol and zinc status, and acute respiratory infections in underweight and normal-weight children aged 6-24... (Publications)
children with zinc insufficiency and those that were serum retinol deficient had 1.2 (95% CI 1.0-1.5) times higher risk of URI and 1.9 (95% CI 1.4-2.6) times higher risk of ALRI, respectively. Thus, our
Approved oncology drugs lack <em>in vivo</em> activity against <em>Trichuris muris</em> despite <em>in vitro</em> activity (Publications)
adult worm stage (> 80 % drug effect at 50 muM), of which six revealed IC50 values between 1.8 and 5.0 muM. Except for tamoxifen citrate, all in vitro active drugs were protein kinase inhibitors. None
Sleep disturbance from road traffic, railways, airplanes and from total environmental noise levels in Montreal (Publications)
was 12.4%. The proportion of those affected by road traffic, airplane and railway noise was 4.2%, 1.5% and 1.1%, respectively. We observed an increased prevalence in sleep disturbance for those exposed
Discovery and characterization of <em>Mycobacterium basiliense</em> sp. nov., a nontuberculous <em>Mycobacterium </em>isolated from human lungs (Publications)
genome sequence was obtained through combining short and long-read sequencing, providing a genome of 5.6 Mb. The genome appears to be highly intact, syntenic with that of M. marinum, with very few insertion
Life cycle maintenance and drug-sensitivity assays for early drug discovery in <em>Schistosoma mansoni</em> (Publications)
along the drug-screening cascade are also described. In these assays, which can be performed within 5 d, the effect of a drug is determined by phenotypic assessment of the parasites' viability and morphology
Quantification of viable bacterial load in artificial sputum spiked with <em>Mycobacterium tuberculosis</em> (Publications)
were well grouped around the mean TTP (hours; standard deviation) of low: 271.7 (25.9), medium: 233.5 (16.3), and two batches of high load: 186.9 (12.3) and 191.8 (9.0), respectively. A variance component
Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed,... (Publications)
materials was required. Potentially etiologically relevant pathogens could be identified by NGS in 5 out of 17 samples of patients with invasive mycoses and in 1 out of 6 samples of patients with amebiasis
Molecular epidemiology and whole genome sequencing analysis of clinical <em>Mycobacterium bovis</em> from Ghana (Publications)
global collection of published M. bovis genomes. RESULTS: Mycobacterium bovis was isolated from 3/560(0.5%) females and 12/1195(1.0%) males with pulmonary TB. The average age of M. bovis infected cases was
Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of <em>Plasmodium falciparum</em>... (Publications)
frequent than 0.77%. In 58 patients treated with atovaquone/proguanil, Tyr268Ser was present in 1 of 5 patients with treatment failure but in 0 of 53 successfully treated patients. CONCLUSIONS: Tyr268Ser
