Human monocytotropic ehrlichiosis: a systematic review and analysis of the literature (Publications)
(9.9%) and immunocompromized (16.3%) cases, and sequelae are rare (4.2% in immunocompetent cases, 2.5% in immunocompromised cases).
Different classes of genomic inserts contribute to human antibody diversity (Publications)
malaria parasites, non-VDJ inserts were detected in 80% of individuals at frequencies of 1 in 10(4) to 10(5) B cells. We detected insertions in heavy, but not in light chain or T cell receptor transcripts. We
Stringency of COVID-19 containment response policies and air quality changes: a global analysis across 1851 cities (Publications)
149 countries, after controlling for the impacts of relevant covariates (e.g., meteorology), Sentinel-5P satellite-observed nitrogen dioxide (NO2) levels decreased by 4.9% (95% CI: 2.2, 7.6%) during lockdowns
Projected impact of heat on mortality and labour productivity under climate change in Switzerland (Publications)
y amount to around CHF 665 million (approx. USD 700 million) per year. Should we remain on an RCP8.5 emissions pathway, these values may double (for mortality) or even triple (for labour productivity)
Microbiological characterisation of community-acquired urinary tract infections in Bagamoyo, Tanzania: a prospective study (Publications)
time-of-flight (MALDI-TOF) mass spectrometry and automated resistance testing. Overall, 104 out of 270 (38.5%) individuals had a positive urine culture and 119 putative pathogens were identified. The most frequently
Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership (Publications)
and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in
Introduction to a landscape analysis of multisectoral approaches for prevention and control of infectious and vector-borne diseases (Publications)
project supported several activities, including commissioning a series of scientific reviews on MSAs in 5 thematic areas, sharing the key findings of these reviews in workshops and events, and developing a
Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus (Publications)
Subgroup analysis was performed for additional PCT measurements in the first 48 hours of SE. RESULTS: 22.5% of 160 consecutive SE patients had infections during SE. Single levels of CRP and WBC had no association
Inhibition of <em>Plasmodium falciparum</em> fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids (Publications)
microM), the more complex flavonoids (12-16) exhibited strong activity toward all three enzymes (IC50 0.5-8 microM). Isoflavonoids 26-28 showed moderate (IC50 7-30 microM) but selective activity against FabZ
Approved oncology drugs lack <em>in vivo</em> activity against <em>Trichuris muris</em> despite <em>in vitro</em> activity (Publications)
adult worm stage (> 80 % drug effect at 50 muM), of which six revealed IC50 values between 1.8 and 5.0 muM. Except for tamoxifen citrate, all in vitro active drugs were protein kinase inhibitors. None