The association of increased pre- and postnatal NO2 and PM2.5 exposure with the infant nasal microbiome composition and respiratory symptoms (Publications)
were 21.54 μg/m(3) (NO(2)) and 13.84 μg/m(3) (PM(2.5)) (WHO guideline limits: NO(2): 40 μg/m(3) (2005), 10 μg/m(3) (2021); PM(2.5): 10 μg/m(3) (2005), 5 μg/m(3) (2021)). We identified two distinct microbiome [...] investigated the association of pre- and postnatal nitrogen dioxide (NO(2)) and particulate matter ≤2.5 μm (PM(2.5)) with microbiome at 4-6 weeks and with respiratory symptoms during the first year of life. H [...] NO(2): odds ratio 1.58, 95% confidence interval 1.08; 2.29, p(adj) =...
Long-lasting insecticidal nets retain bio-efficacy after 5 years of storage: implications for malaria control programmes (Publications)
effective LLINs in endemic areas are required. This study evaluated whether LLINs that had been stored for 5 years under manufacturer's recommended conditions may be optimally effective against Anopheles mosquitoes [...] y and wash resistance of Olyset((R)) and DawaPlus((R)) 2.0 (rebranded Tsara((R)) Soft) LLINs after 5 years of storage at 25 degrees C to 33.4 degrees C and 40% to 100% relative humidity. In addition, a [...] s.) (Ifakara strain) and pyrethroid resistant Anopheles arabiensis...
Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among... (Publications)
Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income). [...] Cost-Effectiveness poLicy (MCMARCEL) was developed to follow RSV-related events monthly from birth until 5 years of age. MCMARCEL was parameterised using country- and age-specific demographic, epidemiological
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity (Publications)
existing therapies are partially ineffective and cause serious adverse effects. Formation of the PEX14-PEX5 complex is essential for protein import into the parasites' glycosomes. This transport is critical for [...] on of glycosomal enzymes, with fatal consequences for the parasite. Hence, inhibiting the PEX14-PEX5 protein-protein interaction (PPI) is an attractive way to affect multiple metabolic pathways. Herein [...] computational screening and optimization to develop the first line of...
Gesundheitsrisiko Mobilfunkstrahlung? Was ändert sich mit 5G? (Publications)
guideline values. With increasing mobile data usage and the associated use of higher frequencies for 5G, a densification of the mobile network is to be expected. However, this will not necessarily increase [...] the overall RF-EMF exposure of the population, as mobile phones emit less with better signal quality. 5G is a technological advancement of the previous mobile radio technology with the same biophysical properties
Mortality risk attributable to wildfire-related PM2.5 pollution: a global time series study in 749 locations (Publications)
between wildfire-related PM2.5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2.5 and mortality across various [...] wildfire-related PM2.5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0.25 degrees x 0.25 degrees resolution. The association between wildfire-related PM2.5 exposure and mortality [...] attributable to the acute impacts of wildfire-related PM2.5...
Long-term exposures to PM2.5, black carbon and NO2 and prevalence of current rhinitis in French adults: the constances cohort (Publications)
BACKGROUND: Rhinitis is one of the most common disease worldwide with a high and increasing prevalence. There is limited knowledge on the link between long-term exposure to air pollution and rhinitis.