Mortality risk attributable to wildfire-related PM2.5 pollution: a global time series study in 749 locations (Publications)
between wildfire-related PM2.5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2.5 and mortality across various [...] wildfire-related PM2.5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0.25 degrees x 0.25 degrees resolution. The association between wildfire-related PM2.5 exposure and mortality [...] attributable to the acute impacts of wildfire-related PM2.5...
Long-term exposures to PM2.5, black carbon and NO2 and prevalence of current rhinitis in French adults: the constances cohort (Publications)
BACKGROUND: Rhinitis is one of the most common disease worldwide with a high and increasing prevalence. There is limited knowledge on the link between long-term exposure to air pollution and rhinitis.
<em>In vitro, in vivo</em>, and ADME evaluation of SF5-containing <em>N,N'</em>-diarylureas as antischistosomal agents (Publications)
at 10 μM), endowed with decent cytotoxicity profile (SI against L6 cells > 8.5) and good microsomal hepatic stability (> 62.5% of drug remaining after 60 min), were tested in S. mansoni infected mice. Despite [...] found. Thus, further investigations are needed to better understand the underlying mechanisms of SF(5)-containing N,N'-diarylureas.
Common haplotypes at the <em>CFH </em>locus and low-frequency variants in <em>CFHR2 </em>and <em>CFHR5 </em>associate with systemic FHR concentrations... (Publications)
in CFHR2 and CFHR5 led to reduced or absent FHR-2 and FHR-5 concentrations (e.g., p.Cys72Tyr in CFHR2 and FHR-2, p = 2.46 x 10(-16)). Finally, we showed localization of FHR-2 and FHR-5 in the choriocapillaris [...] and rare protein-altering CFHR2 and CFHR5 variants associated with AMD independently of all previously reported genome-wide association study (GWAS) signals (p = 5.03 x 10(-3) and p = 2.81 x 10(-6), res [...] elevated systemic levels of FHR-1 (p = 1.84 x 10(-6)), FHR-2 (p = 1.47 x...
<em>Mycobacterium tuberculosis </em>complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to... (Publications)
absent between H37Rv and L5 strains. Additionally, considerable gene content variability was found across L5 strains, including a split in the L5.3 sub-lineage into L5.3.1 and L5.3.2. These gene content [...] lineages (L), especially L5 and L6 (traditionally termed Mycobacterium africanum) strains, from each other. However, this genome variability and gene content, especially of L5 strains, has not been fully [...] genomic analysis of MTBC strains, including transmission studies. By comparing...
Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/preclinical-profiling-of-virosomally-formulated-b-cell-epitope-mimetics-derived-from-the-novel-key-malaria-vaccine-candidates-cyrpa-and-rh5
Clinical testing of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final mult
A triple win awaits (Page)
https://www.swisstph.ch/en/impact-stories/a-triple-win-awaits
travel was undertaken at Swiss TPH. This means that in 2020 the world achieved what was needed for the 1.5 degree target; but unfortunately not with climate policy, but instead COVID-19 lockdowns. This is of [...] greenhouse gas emissions have fallen by around 8% in 2020. The world has achieved what is needed for the 1.5 degree target, not with climate policy, but COVID-19 lockdowns." Climate change is unfair Strikingly [...] many African countries were less than 300kg per person in 2018. In...
Winter Symposium 2019 (Page)
https://www.swisstph.ch/en/about/events/winter-symposium-2019
co-benefits Live-streaming will be available starting at 8:30 on Dec. 5 and 6 for those who are not able to attend in person. Programme Thursday, 5 December 2019 Session PL1 | Setting the Scene 09:15 Where We Stand [...] Tiger Mosquito in Switzerland, Pie Müller, Swiss TPH Session TS5 | Frameworks for Health System Resilience and Disaster Risk Reduction 5a Frameworks 11:10 Sendai Framework for Disaster Risk Reduction, [...] Framework for Modelling Nutrition-Related Health Impacts under Climate...
FAQ (Page)
https://www.swisstph.ch/en/topics/non-communicable-diseases/physical-activity/sophya/faq
Gleichzeitig kann die Belastung der Bevölkerung dank der Stichprobenbefragung gering gehalten werden. 5. Warum bin gerade ich ausgewählt worden? Damit die Studie wissenschaftlich korrekt ist, werden alle