<em>TOLLIP</em> and <em>MUC5B</em> modulate the effect of ambient NO2 on respiratory symptoms in infancy (Publications)
Significant interaction was observed between modelled air pollution (weekly NO(2) exposure) and 5 SNPs within MUC5B and TOLLIP genes regarding respiratory symptoms as outcome: E.g., infants carrying minor alleles [...] BACKGROUND: Current knowledge suggests that the gene region containing MUC5B and TOLLIP plays a role in airway defence and airway inflammation, and hence respiratory disease. It is also known that exposure [...] on the immune response and respiratory symptoms in infants may be...
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
studies of 2,8-disubstituted-1,5-naphthyridines, previously reported as potent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase β (PI4K), identified 1,5-naphthyridines with basic groups
NETCELL Phase 5 - Core support to the National Malaria Control Programme in Tanzania (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/netcell-phase-5-core-support-to-the-national-malaria-control-programme-in-tanzania
is a clear recognition of the organisational and human resource gaps at the NMCP. The proposed Phase 5 of NETCELL will carry forward these changes and focus on achieving three outcomes: The ITN Cell and [...] mentoring component in order to ensure sustainability of the efforts and continuity of results. This Phase 5 of five years will tackle an enlarged scope of support, while at the same time deepen its structural
Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/preclinical-profiling-of-virosomally-formulated-b-cell-epitope-mimetics-derived-from-the-novel-key-malaria-vaccine-candidates-cyrpa-and-rh5
Clinical testing of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final mult
In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative... (Publications)
the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gram-negative bacteria. Therefore, C3 and C5 inhibition increases the risk [...] against complement components other than C3 and C5 may carry a reduced risk of infection, we compared the effect of inhibitors targeting the terminal pathway (C5), the central complement component C3, the [...] H-binding protein (fHbp). SBA triggered by these cell surface...
Hourly land-use regression modeling for NO2 and PM2.5 in the Netherlands (Publications)
performed overall well (5-fold cross validation R(2) = 0.50 - 0.78), while the PM(2.5) performed moderately (5-fold cross validation R(2) = 0.24 - 0.62). Both for NO(2) and PM(2.5) the warm season models [...] this study we aimed to model average hourly concentrations for two major pollutants, NO(2) and PM(2.5), for the Netherlands using the LUR algorithm. We modelled the spatial variation of average hourly [...] models performed overall worse than both modelling approaches (NO(2) hourly R(2) =...
Association between concurrence of multiple risk factors and under-5 mortality: a pooled analysis of data from demographic and health survey in 61... (Publications)
al strategies to address preventable under-5 mortality (U5M). This study aims to assess the associations between concurrence of multiple risk factors and U5M in LMICs. METHODS: We extracted data from the [...] 61 LMICs. Our primary outcome was U5M, defined as deaths from birth to 59 months. Binary logistic regression model was applied to ascertain the association between U5M and a total of 20 critical risk factors [...] factors in each individual and assessed their combined effects on U5M with...
5G Exposure, Causal Effects, and Risk Perception through Citizen Engagement (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/5g-exposure-causal-effects-and-risk-perception-through-citizen-engagement
resulting from 5G deployment; iii) assess neuropsychological effects among young people, and iv) quantify potential health impacts of exposures at the population level; v) assess effects of 5G on brain function [...] remarkable among young people and workers, the most sensitive and exposed groups, respectively. In GOLIAT (5 G exp O sure, causa L effects, and r I sk perception through citizen eng A gemen T ) project ( http [...] vi) identify effective means of exposure reduction; vii) understand...
Community-Based chronic disease Care Lesotho: A 5-year implementation research programme to tackle non-communicable diseases in rural Lesotho (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/community-based-chronic-disease-care-lesotho-a-5-year-implementation-research-programme-to-tackle-non-communicable-diseases-in-rural-lesotho
Non-Communicable Diseases (NCDs) such as diabetes and high blood pressure are the number one cause of death and disability globally. More than 75% of premature NCD-related deaths occur in low- and mid
A triple win awaits (Page)
https://www.swisstph.ch/en/impact-stories/a-triple-win-awaits
travel was undertaken at Swiss TPH. This means that in 2020 the world achieved what was needed for the 1.5 degree target; but unfortunately not with climate policy, but instead COVID-19 lockdowns. This is of [...] greenhouse gas emissions have fallen by around 8% in 2020. The world has achieved what is needed for the 1.5 degree target, not with climate policy, but COVID-19 lockdowns." Climate change is unfair Strikingly [...] many African countries were less than 300kg per person in 2018. In...
