Safety of co-administration versus separate administration of the same vaccines in children: a systematic literature review (Publications)
studies reported significantly more adverse events following immunization (AEFI) while in 10% (n = 5) significantly fewer adverse events were found in the co-administration groups. Statistically significant
Physiologically based pharmacokinetic modelling to identify pharmacokinetic parameters driving drug exposure changes in the elderly (Publications)
y simulated for all ten drugs. Pharmacokinetic parameters were predicted within 1.25-fold (70%), 1.5-fold (86%) and 2-fold (100%) of clinical data. AUC increased progressively by 0.9% per year throughout
Impact and cost-effectiveness of snail control to achieve disease control targets for schistosomiasis (Publications)
focal snail control interventions against Schistosoma haematobium across a range of low-prevalence (5-20%) and high-prevalence (25-50%) rural Kenyan communities. We simulated strategies over a 10-year period
Prognostic value of quickSOFA as a predictor of 28-day mortality among febrile adult patients presenting to emergency departments in Dar es Salaam,... (Publications)
causes of infections were the respiratory tract (43%), dengue (26%), malaria (6%) and typhoid fever (5%). Twenty-eight-day all-cause mortality was 6%: 3% for patients with a qSOFA /=2 (absolute difference
Caregiver depression is associated with hair cortisol in a low-income sample of preschool-aged children (Publications)
preschool-aged children. METHODS: 154 caregivers comprised mostly of mothers and their children (2-to-5 years) who were enrolled in a birth cohort study conducted in poor urban neighborhoods of Sao Paulo
Current use and costs of electronic health records for clinical trial research: a descriptive study (Publications)
the 17 EHR-supported trials varied from US$44 to US$2000, and total RCT costs from US$67 750 to US$5 026 000. In the remaining 172 RCTs (91.0%), EHRs were used as a modality of intervention. INTERPRETATION:
Multicentre assessment of motor and sensory evoked potentials in multiple sclerosis: reliability and implications for clinical trials (Publications)
changes from 0.4 to 1.8 ms and 0.36 to 0.62, within-subject minimal detectable change from 1.2 to 5.8 ms and 1.2 to 2.0, within-subject improvement from 0.8 to 3.8ms and 0.8 to 1.3, for single EP modalities
Evaluation of the novel substrate RUG™ for the detection of<em> Escherichia coli</em> in water from temperate (Zurich, Switzerland) and tropical... (Publications)
m-ColiBlue24®. In temperate waters, AT-RUG was found to be as sensitive as m-TEC (97.0%) and C-18 (98.5%) and showed strong agreement with the reference methods. The false-positive rate for E. coli detection
<em>Mycobacterium tuberculosis</em> lineage 1 genetic diversity in Para, Brazil, suggests common ancestry with east-African isolates potentially... (Publications)
a poor correlation with SNP data and are not monophyletic. L1/EAI8-MDG and L1/EAI3-IND belonged to C5; this result suggests that they share a common ancestor. L1.1.3/SIT129, a spoligotype pattern found
Cost-effectiveness of tuberculosis screening for migrant children in a low-incidence country (Publications)
(15.4%). Screening for LTBI was cost-effective if LTBI prevalence was 14%, with a progression rate of 5%; in case of lower LTBI prevalence, LTBI screening is cost-effective if progression rates to active