Long term exposure to air pollution and kidney parenchyma cancer - effects of low-level air pollution: a study in Europe (ELAPSE) (Publications)
during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO(2), PM(2.5), BC and O(3) were 24.1 μg/m(3) (12.8-39.2), 15.3 μg/m(3) (8.6-19.2), 1.6 10(-5) m(-1) (0 [...] interval [CI]: 0.92, 1.15) per 10 μg/m³ NO(2), 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM(2.5), 0.99 (95% CI: 0.89, 1.11) per 0.5 10(-5) m(-1) BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O(3). We did not [...] residential exposure to fine particles (PM(2.5)), nitrogen dioxide (NO(2)),...
Performance of multi-cities land use regression models for nitrogen dioxide and fine particles (Publications)
for NO2, 86% for PM2.5 and 70% for PM2.5 absorbance. The HV R2s were only slightly lower than the model R2 (NO2: 54%, PM2.5: 80%, absorbance: 70%). The European NO2, PM2.5 and PM2.5 absorbance models explained [...] development. METHODS: We evaluated LUR models for nitrogen dioxide (NO2) and Particulate Matter (PM2.5, PM2.5 absorbance) by combining standardized measurement data from 17 (PM) and 23 (NO2) ESCAPE study areas [...] fraction of variability in areas which were excluded from model...
Antigen rapid tests, nasopharyngeal PCR and saliva PCR to detect SARS-CoV-2: a prospective comparative clinical trial (Publications)
9-43.3%) by NP PCR, and 41.5% (38.3-44.7%) by any test. For those with viral loads (VL) > /=106 copies/ml, detection rates were 30.3% (27.3-33.3), 31.4% (28.4-34.5), 31.5% (28.5-34.6), and 31.6% (28.6-34 [...] RDT compared to NP PCR was 87.4% (83.6-90.6%) for all positive patients, 94.5% (91.5-96.7%) for those with VL> /=105 and 96.5% (93.6-98.3%) for those with VL> /=106. Sensitivity of STANDARD-Q(R), Panbio [...] 9-89.7%), respectively. For those with VL> /=106, sensitivity was 96.6% (90.5-99....
Antigen rapid tests, nasopharyngeal PCR and saliva PCR to detect SARS-CoV-2: a prospective comparative clinical trial (Publications)
9-43.3%) by NP PCR, and 41.5% (38.3-44.7%) by any test. For those with viral loads (VL) > /=106 copies/ml, detection rates were 30.3% (27.3-33.3), 31.4% (28.4-34.5), 31.5% (28.5-34.6), and 31.6% (28.6-34 [...] RDT compared to NP PCR was 87.4% (83.6-90.6%) for all positive patients, 94.5% (91.5-96.7%) for those with VL> /=105 and 96.5% (93.6-98.3%) for those with VL> /=106. Sensitivity of STANDARD-Q(R), Panbio [...] 9-89.7%), respectively. For those with VL> /=106, sensitivity was 96.6% (90.5-99....
Performance of multi-cities land use regression models for nitrogen dioxide and fine particles (Publications)
for NO2, 86% for PM2.5 and 70% for PM2.5 absorbance. The HV R2s were only slightly lower than the model R2 (NO2: 54%, PM2.5: 80%, absorbance: 70%). The European NO2, PM2.5 and PM2.5 absorbance models explained [...] development. METHODS: We evaluated LUR models for nitrogen dioxide (NO2) and Particulate Matter (PM2.5, PM2.5 absorbance) by combining standardized measurement data from 17 (PM) and 23 (NO2) ESCAPE study areas [...] fraction of variability in areas which were excluded from model...
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (Publications)
best inhibitors included the compounds 5'-tritylamino-2',5'-dideoxyuridine (2j) (Ki = 0.2 microM) and 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine (5h) (Ki = 1.3 microM), with selectivity greater [...] is described in which the substituents are introduced at the 3'- and 5'-positions, together with variation in the heteroatom at the 5'-position. The compounds were assayed against recombinant Plasmodium [...] a structure-activity study...
Longer delays in diagnosis and treatment of pulmonary tuberculosis in pastoralist setting, Eastern Ethiopia (Publications)
health system and total delays were 30 (19–48.5), 14 (4.5–29.5) and 50 (35–73.5) days, respec-tively. The median patient delay (35.5 days) and total delay (58.5 days) among pastoralists were substantially [...] and Methods: A cross-sectional study among 444 confirmed new pulmonary TB patients aged ≥15 years in 5 TB care units was conducted between December 2017 and October 2018. Data were collected using a structured
Longer delays in diagnosis and treatment of pulmonary tuberculosis in pastoralist setting, Eastern Ethiopia (Publications)
health system and total delays were 30 (19–48.5), 14 (4.5–29.5) and 50 (35–73.5) days, respec-tively. The median patient delay (35.5 days) and total delay (58.5 days) among pastoralists were substantially [...] and Methods: A cross-sectional study among 444 confirmed new pulmonary TB patients aged ≥15 years in 5 TB care units was conducted between December 2017 and October 2018. Data were collected using a structured
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (Publications)
best inhibitors included the compounds 5'-tritylamino-2',5'-dideoxyuridine (2j) (Ki = 0.2 microM) and 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine (5h) (Ki = 1.3 microM), with selectivity greater [...] is described in which the substituents are introduced at the 3'- and 5'-positions, together with variation in the heteroatom at the 5'-position. The compounds were assayed against recombinant Plasmodium [...] a structure-activity study...
Long-term exposure to ambient air pollution and asthma symptom score in the CONSTANCES cohort (Publications)
lower than 2.5 microm (PM2.5), black carbon (BC) and NO2 and the asthma symptom score in adults from CONSTANCES, a French population-based cohort. METHODS: Asthma symptom score (range: 0-5) was based on [...] independent of total PM2.5 was investigated with a residual model. RESULTS: Analyses were conducted on 135 165 participants (mean age: 47.2 years, 53.3% women, 19.0% smokers, 13.5% ever asthma). The ratio [...] 14 (95% CI 1.12 to 1.16) and 1.12 (95% CI 1.10 to 1.14) per one IQR increase of...
