Smoking cessation, lung function, and weight gain: a follow-up study (Publications)
3) and -5.1 mL (-7.5 to -2.8), respectively. These sex differences were not significant. FEV1 changed by -11.5 mL (-13.3 to -9.6) per kg weight gained in men, and by -3.7 mL per kg (-5.0 to -2.5) in women [...] difference 5.4 mL per year, 95% CI 1.7 to 9.1) and those who quit between surveys (2.5 mL, -1.9 to 7.0), and greater in smokers (-4.8 mL, -7.9 to -1.6). In women, estimates were 1.3 mL per year (-1.5 to 4.1)
Synthesis and antiprotozoal activity of aza-analogues of furamidine (Publications)
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a), through the bis-O-acetoxyamidoxime followed by hydrogenation. Compound 4a [...] 4c and 4d, respectively. N-Methoxy-6-[5-[4-(N-methoxyamidino)phenyl]-furan-2-yl]-nicotinamidine (6a) was prepared via methylation of the respective diamidoxime 5a with dimethylsulfate. Prodrugs 6b and [...] and 6c were also prepared by methylation of the respective diamidoximes 5b and 5d. The...
Synthesis and antiprotozoal activity of aza-analogues of furamidine (Publications)
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a), through the bis-O-acetoxyamidoxime followed by hydrogenation. Compound 4a [...] 4c and 4d, respectively. N-Methoxy-6-[5-[4-(N-methoxyamidino)phenyl]-furan-2-yl]-nicotinamidine (6a) was prepared via methylation of the respective diamidoxime 5a with dimethylsulfate. Prodrugs 6b and [...] and 6c were also prepared by methylation of the respective diamidoximes 5b and 5d. The...
Smoking cessation, lung function, and weight gain: a follow-up study (Publications)
3) and -5.1 mL (-7.5 to -2.8), respectively. These sex differences were not significant. FEV1 changed by -11.5 mL (-13.3 to -9.6) per kg weight gained in men, and by -3.7 mL per kg (-5.0 to -2.5) in women [...] difference 5.4 mL per year, 95% CI 1.7 to 9.1) and those who quit between surveys (2.5 mL, -1.9 to 7.0), and greater in smokers (-4.8 mL, -7.9 to -1.6). In women, estimates were 1.3 mL per year (-1.5 to 4.1)
Burden of disease in Germany attributed to ambient particulate matter pollution : findings from the Global Burden of Disease Study 2019 (Publications)
INTRODUCTION: Ambient fine particulate matter pollution with a diameter less than 2.5 micrometers (PM(2.5)) is a significant risk factor for chronic noncommunicable diseases (NCDs), leading to a substantial [...] years lived with disability (YLDs), and deaths attributed to ambient PM(2.5) pollution in Germany. RESULTS: In 2019, ambient PM(2.5) pollution in Germany was associated with significant health impacts, c [...] disease burden associated with ambient PM(2.5) pollution in Germany from...
microRNA expression profiles and personal monitoring of exposure to particulate matter (Publications)
hsa-miR-4454, hsa-miR-4763-3p, hsa-miR-425-5p, hsa-let-7d-5p, hsa-miR-502-5p, and hsa-miR-505-3p were significantly (FDR corrected) expressed in association with PM2.5 personal exposure, while no significant [...] present study, we investigated the relationship between particulate matter (PM) smaller than 2.5 mum (PM2.5), PM2.5 absorbance (as a proxy of black carbon and soot), and ultrafine-particles (UFP, smaller than [...] other pollutants. The results obtained from this investigation suggest...
Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort (Publications)
16) per 50 ng/m(3) PM2.5 K, 1.09 (95% CI 1.02, 1.15) per 1 ng/m(3) PM2.5 Ni, 1.22 (95% CI 1.11, 1.35) per 200 ng/m(3) PM2.5 S, and 1.07 (95% CI 1.02, 1.12) per 200 ng/m(3) PM2.5 V. Effect estimates were [...] association between long-term exposure to fine particulate matter (PM2.5) and lung cancer has been established in previous studies. PM2.5 is a complex mixture of chemical components from various sources and [...] specific elemental components of PM2.5 and lung cancer incidence. METHODS: We...
Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort (Publications)
16) per 50 ng/m(3) PM2.5 K, 1.09 (95% CI 1.02, 1.15) per 1 ng/m(3) PM2.5 Ni, 1.22 (95% CI 1.11, 1.35) per 200 ng/m(3) PM2.5 S, and 1.07 (95% CI 1.02, 1.12) per 200 ng/m(3) PM2.5 V. Effect estimates were [...] association between long-term exposure to fine particulate matter (PM2.5) and lung cancer has been established in previous studies. PM2.5 is a complex mixture of chemical components from various sources and [...] specific elemental components of PM2.5 and lung cancer incidence. METHODS: We...
Development and evaluation of a personal particulate organic and mass sampler (Publications)
outdoor site, and in residences. Daily particulate mass concentrations averaged 10.0 +/- 5.2, 12.0 +/- 5.3, and 11.2 +/- 5.1 microg m(-3) for the Federal Reference Method, the Harvard Personal Exposure Monitor [...] a series of PM2.5 indoor organic carbon (OC) measurements from single quartz filters, the apparent indoor OC averaged 7.7 +/- 0.8 microg of C m(-3), which was close to the indoor PM2.5 mass from collocated [...] developed to meet these criteria. The PPOMS uses activated...
Development and evaluation of a personal particulate organic and mass sampler (Publications)
outdoor site, and in residences. Daily particulate mass concentrations averaged 10.0 +/- 5.2, 12.0 +/- 5.3, and 11.2 +/- 5.1 microg m(-3) for the Federal Reference Method, the Harvard Personal Exposure Monitor [...] a series of PM2.5 indoor organic carbon (OC) measurements from single quartz filters, the apparent indoor OC averaged 7.7 +/- 0.8 microg of C m(-3), which was close to the indoor PM2.5 mass from collocated [...] developed to meet these criteria. The PPOMS uses activated...
