Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study (Publications)
interval [CI]: 1.13, 1.70 per 10 microg/m(3)), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 microg/m(3)), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 x 10(-5)/m) with psychiatric disorders mortality, as well [...] residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression [...] 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08...
Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study (Publications)
interval [CI]: 1.13, 1.70 per 10 microg/m(3)), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 microg/m(3)), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 x 10(-5)/m) with psychiatric disorders mortality, as well [...] residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression [...] 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08...
Configurationally stabilized analogs of <em>M. ulcerans</em> exotoxins mycolactones A and B reveal the importance of side chain geometry for... (Publications)
isomers about the C4' horizontal lineC5' double bond of the C5-side chain. Here, we describe the syntheses of mycolactone analogs with configurationally stable C5-side chains (2a, E mimetic; 2b/c, Z mimetics) [...] mimetics). Based on the cytotoxicity of 2a-c, the Delta(4',5')-trans isomer of mycolactones A/B (1b) appears to be the major virulence factor.
Configurationally stabilized analogs of <em>M. ulcerans</em> exotoxins mycolactones A and B reveal the importance of side chain geometry for... (Publications)
isomers about the C4' horizontal lineC5' double bond of the C5-side chain. Here, we describe the syntheses of mycolactone analogs with configurationally stable C5-side chains (2a, E mimetic; 2b/c, Z mimetics) [...] mimetics). Based on the cytotoxicity of 2a-c, the Delta(4',5')-trans isomer of mycolactones A/B (1b) appears to be the major virulence factor.
Impact of population aging on future temperature-related mortality at different global warming levels (Publications)
show that at 1.5 °C, 2 °C, and 3 °C of global warming, heat-related mortality in 800 locations across 50 countries/areas will increase by 0.5%, 1.0%, and 2.5%, respectively; among which 1 in 5 to 1 in 4 h [...] mostly counteract this trend, leading to a net increase in cold-related mortality by 0.1%-0.4% at 1.5-3 °C global warming. Our findings indicate that population aging constitutes a crucial driver for future
Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles (Publications)
2,4-oxadiazol-5-yl)methyl)-5-phenyl-1,6a-dihydropyrrolo[3,4-d][1 ,2,3] triazole-4,6(3aH,5H)-diones (5a-k) was designed and synthesized by the 1,3-dipolar cycloaddition reaction of novel 5-azidomethyl 3-aryl
Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles (Publications)
2,4-oxadiazol-5-yl)methyl)-5-phenyl-1,6a-dihydropyrrolo[3,4-d][1 ,2,3] triazole-4,6(3aH,5H)-diones (5a-k) was designed and synthesized by the 1,3-dipolar cycloaddition reaction of novel 5-azidomethyl 3-aryl
Impact of population aging on future temperature-related mortality at different global warming levels (Publications)
show that at 1.5 °C, 2 °C, and 3 °C of global warming, heat-related mortality in 800 locations across 50 countries/areas will increase by 0.5%, 1.0%, and 2.5%, respectively; among which 1 in 5 to 1 in 4 h [...] mostly counteract this trend, leading to a net increase in cold-related mortality by 0.1%-0.4% at 1.5-3 °C global warming. Our findings indicate that population aging constitutes a crucial driver for future
Understanding the social determinants of child mortality in Latin America over the last two decades: a machine learning approach (Publications)
for predicting U5MR according to the RF. Furthermore, non-linear relationships were found mainly for Gini index and U5MR. Our study suggests that long-term public policies to reduce U5MR in Latin America [...] learning (ML) algorithms to explore the relationship between social determinants and child under-5 mortality rates (U5MR) in Brazil, Ecuador, and Mexico over two decades. We created a municipal-level cohort from [...] random forest model (RF) to estimate the relative importance of social...
Chronic lung function decline in cotton textile workers: roles of historical and recent exposures to endotoxin (Publications)
stratified by active versus retired work status and by years employed before the baseline survey ( < 5 and > or = 5 years). RESULTS AND CONCLUSIONS: Past exposure to endotoxin was associated with reduced FEV1 [...] exposure was more strongly associated with reduced FEV1 for those hired < 5 years before baseline than for those who were hired > or = 5 years after baseline. Recent endotoxin exposure was significantly associated [...] This prospective cohort study followed 447 cotton textile workers...