Substantial reduction in particulate matter air pollution across Europe during 2006-2019: a spatiotemporal modeling analysis (Publications)
results show that during the last 14 years, PM10 and PM2.5 concentrations declined by 36.5% (95% credible interval: 30.3, 41.9%) and 39.1% (26.6, 50.5%), respectively. The number of people exposed to PM10 [...] 6, 91.8%) in 2006 to 28.4% (16.2, 43.7%) in 2019; for PM2.5, the decrease was smaller: from 91.0% (61.3, 99.1%) exposed in 2006 to 53.6% (33.5, 76.3%) in 2019. Although there is a clear improvement in [...] models and for the first time estimate pan-European near-surface concentrations...
Long-term exposure to source-specific fine particles and mortality horizontal line a pooled analysis of 14 European cohorts within the ELAPSE project (Publications)
oil-related PM2.5 had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5 mass, suggesting that past estimates using the generic PM2.5 exposure [...] fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5 identified through [...] source apportionment analysis. Exposure to 2010 annual average...
Representative seroprevalences of brucellosis in humans and livestock in Kyrgyzstan (Publications)
nces of brucellosis were 8.8% in humans (95% CI 4.5-16.5), 2.8% (95% CI 1.6-4.9%) in cattle, 3.3% (95% CI 1.5-6.9%) in sheep, and 2.5% (95% CI 1.4-4.5%) in goats. Naryn Oblast had the highest seroprevalences [...] Kyrgyzstan reported 77.5 new human brucellosis cases per 100,000 people in 2007, which is one of the highest incidences worldwide. In Kyrgyzstan, the currently used diagnostic tests in humans and animals
Cancer risk assessment of selected hazardous air pollutants in Seattle (Publications)
cancer risk was 6.09 x 10(-5), with the background (1.61 x 10(-5)), diesel (9.82 x 10(-6)) and wood burning (9.45 x 10(-6)) sources being the primary risk sources. The PM(2.5) mass concentration contributed [...] lifetime excess cancer risks of selected hazardous air pollutants. We analyzed the speciated PM(2.5) and VOCs data collected at the Beacon Hill in Seattle, WA between 2000 and 2004 with the Multilinear [...] contributed 20% of the total risk. The 5th percentile of the risk estimates of...
Representative seroprevalences of brucellosis in humans and livestock in Kyrgyzstan (Publications)
nces of brucellosis were 8.8% in humans (95% CI 4.5-16.5), 2.8% (95% CI 1.6-4.9%) in cattle, 3.3% (95% CI 1.5-6.9%) in sheep, and 2.5% (95% CI 1.4-4.5%) in goats. Naryn Oblast had the highest seroprevalences [...] Kyrgyzstan reported 77.5 new human brucellosis cases per 100,000 people in 2007, which is one of the highest incidences worldwide. In Kyrgyzstan, the currently used diagnostic tests in humans and animals
Ambient air pollution and cardiorespiratory outcomes amongst adults residing in four informal settlements in the western province of South Africa (Publications)
Land-Use Regression for Particulate Matter (PM2.5) and Nitrogen Dioxide (NO2) at participants' homes. The median age of the participants was 40.7 years, and 88.5% were female. The median annual NO2 level was [...] annual PM2.5 level was 9.7 microg/m(3) (IQR: 7.3-12.4). Logistic regression analysis was used to assess associations between outcome variables and air pollutants. An interquartile range increase of 5.12 microg/m(3) [...] microg/m(3) in PM2.5 was significantly associated with an...
Long-term exposure to source-specific fine particles and mortality horizontal line a pooled analysis of 14 European cohorts within the ELAPSE project (Publications)
oil-related PM2.5 had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5 mass, suggesting that past estimates using the generic PM2.5 exposure [...] fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5 identified through [...] source apportionment analysis. Exposure to 2010 annual average...
Substantial reduction in particulate matter air pollution across Europe during 2006-2019: a spatiotemporal modeling analysis (Publications)
results show that during the last 14 years, PM10 and PM2.5 concentrations declined by 36.5% (95% credible interval: 30.3, 41.9%) and 39.1% (26.6, 50.5%), respectively. The number of people exposed to PM10 [...] 6, 91.8%) in 2006 to 28.4% (16.2, 43.7%) in 2019; for PM2.5, the decrease was smaller: from 91.0% (61.3, 99.1%) exposed in 2006 to 53.6% (33.5, 76.3%) in 2019. Although there is a clear improvement in [...] models and for the first time estimate pan-European near-surface concentrations...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal [...] anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal [...] anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.