Land use regression modelling of outdoor NO2 and PM2.5 concentrations in three low income areas in the Western Cape Province, South Africa (Publications)
NO(2) and PM2.5 were 22.1 μg/m(3) and 10.2 μg/m(3), respectively. The NO(2) models for the warm season, cold season, and overall year explained 62%, 77%, and 76% of the variance (R(2)). The PM2.5 annual models [...] Explanatory power for PM2.5 models is lower due to lower spatial variability and the possible impact of local transient sources. The study was able to provide NO(2) and PM2.5 seasonal exposure estimates [...] can help to inform communities, industries, and policy makers. Weekly...
Long-lasting insecticidal nets retain bio-efficacy after 5 years of storage: implications for malaria control programmes (Publications)
effective LLINs in endemic areas are required. This study evaluated whether LLINs that had been stored for 5 years under manufacturer's recommended conditions may be optimally effective against Anopheles mosquitoes [...] y and wash resistance of Olyset((R)) and DawaPlus((R)) 2.0 (rebranded Tsara((R)) Soft) LLINs after 5 years of storage at 25 degrees C to 33.4 degrees C and 40% to 100% relative humidity. In addition, a [...] s.) (Ifakara strain) and pyrethroid resistant Anopheles arabiensis...
Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among... (Publications)
Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income). [...] Cost-Effectiveness poLicy (MCMARCEL) was developed to follow RSV-related events monthly from birth until 5 years of age. MCMARCEL was parameterised using country- and age-specific demographic, epidemiological
Novel 1-methyl-1 <em>H</em>-pyrazole-5-carboxamide derivatives with potent anthelmintic activity (Publications)
the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyrazole-5-carboxamide derivatives. Medicinal chemistry optimization targeted modifications of the left-hand side
Knowledge and practices of mothers and caregivers on diarrhoeal management among under 5-year-old children in a medium-size town of Senegal (Publications)
under 5 years of age were included. Slightly less than a quarter (23.2%, 95% confidence interval (CI) 18.9-27.8%) of respondents had good management practice of diarrhoea, while 40.0% (95% CI: 34.5-45.6%) [...] study assessed knowledge and practices of mothers and caregivers on diarrhoeal management among under 5-year-old children in a medium-size town of Senegal. A cross-sectional survey was carried out between [...] located in the south-western part of Senegal. Mothers and caregivers of...
Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A–D, from a... (Publications)
B4 (4), and four related 5,8′-linked monomeric alkaloids, named ikelacongolines A–D (5a, 5b, 6, and 7). The dimers 3 and 4 are structurally unusual quateraryls comprising two 5,8′-coupled monomers linked [...] were isolated from the here investigated Congolese liana, three of them belonging to the subclass of 5,8′-coupled naphthylisoquinoline alkaloids, whereas two compounds exhibited a less frequently occurring
A 5-year intervention study on elimination of urogenital schistosomiasis in Zanzibar: parasitological results of annual cross-sectional surveys (Publications)
interval (CI): 4.5%-7.6%) to 1.7% (95% CI: 1.2%-2.2%) in 9- to 12-year old students, from 3.9% (95% CI: 2.8%-5.0%) to 1.5% (95% CI: 1.0%-2.0%) in adults, and from 8.8% (95% CI: 6.5%-11.2%) to 2.6% (95% [...] public health problem from Pemba and to interrupt Schistosoma haematobium transmission from Unguja in 5 years. METHODOLOGY: A repeated cross-sectional cluster-randomized trial was implemented from 2011/12 [...] (95% CI: 1.7%-3.5%) in 1st year students from 2011/12 to 2017. In 2017, heavy...