Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese <em>Ancistrocladus</em> liana and their... (Publications)
further new dimeric analogs, michellamines B4 (3) and B5 (4), were obtained, along with two previously likewise unknown monomers, ancistrobonsolines A1 (5) and A2 (6), which, besides one single known other [...] the highest cytotoxic activities, comparable to that of the standard agent, 5-fluorouracil. Furthermore, ancistrobonsolines A1 (5) and A2 (6) showed weak-to-moderate antiprotozoal activities. [...] Michellamines A6 (1) and A7 (2) are the first dimers of 5,8′-coupled naphthylisoquinoline...
A var gene upstream element controls protein synthesis at the level of translation initiation in <em>Plasmodium falciparum</em> (Publications)
control has recently been identified for the var2csa gene, where an mRNA element in the 5' untranslated region (5' UTR) is involved in the reversible inhibition of translation of var2csa transcripts. Here [...] var gene regulation to the common upsC type. We identified a 5' UTR sequence that inhibits translation of upsC-derived mRNAs. Importantly, this 5' UTR element efficiently inhibits translation even in the [...] epigenetic silencing. Singular gene choice is controlled at the level of...
A var gene upstream element controls protein synthesis at the level of translation initiation in <em>Plasmodium falciparum</em> (Publications)
control has recently been identified for the var2csa gene, where an mRNA element in the 5' untranslated region (5' UTR) is involved in the reversible inhibition of translation of var2csa transcripts. Here [...] var gene regulation to the common upsC type. We identified a 5' UTR sequence that inhibits translation of upsC-derived mRNAs. Importantly, this 5' UTR element efficiently inhibits translation even in the [...] epigenetic silencing. Singular gene choice is controlled at the level of...
Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese <em>Ancistrocladus</em> liana and their... (Publications)
further new dimeric analogs, michellamines B4 (3) and B5 (4), were obtained, along with two previously likewise unknown monomers, ancistrobonsolines A1 (5) and A2 (6), which, besides one single known other [...] the highest cytotoxic activities, comparable to that of the standard agent, 5-fluorouracil. Furthermore, ancistrobonsolines A1 (5) and A2 (6) showed weak-to-moderate antiprotozoal activities. [...] Michellamines A6 (1) and A7 (2) are the first dimers of 5,8′-coupled naphthylisoquinoline...
Methodological framework for assessing malaria risk associated with climate change in Côte d'Ivoire (Publications)
Attieen and the mountainous climates. By 2050, the IPCC representative concentration pathway (RCP) 4.5 and 8.5 scenarios predict an increase in risk in almost all climatic zones, compared to current levels, [...] around 2040 followed by a decline and RCP 8.5 giving the highest baseline emissions scenario, in which emissions continue to rise. It is expected that the AR5 approach to climate risk analysis will be [...] distribution of its risk in all climatic zones of the country based on the...
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
drug for the treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] > /= 5 years of age) were followed-up after treatment with injectable artesunate for severe [...] patients. A decrease in Hb levels between 2 and 5 g/dL was detected in 23 (11.4%) patients during the follow-up period. For five patients, Hb levels decreased below 5 g/dL during at least one follow-up visit
Predicting airborne particle levels aboard Washington State school buses (Publications)
e matter (PM2.5) aboard school buses as part of a larger study examining the respiratory health impacts of emission reducing retrofits. To assess onboard concentrations, continuous PM2.5 data were collected [...] regression models for PM2.5 onboard buses were created with and without control for roadway concentrations, which were also modeled. Predictors examined included ambient PM2.5 levels, ambient weather, and
Predicting airborne particle levels aboard Washington State school buses (Publications)
e matter (PM2.5) aboard school buses as part of a larger study examining the respiratory health impacts of emission reducing retrofits. To assess onboard concentrations, continuous PM2.5 data were collected [...] regression models for PM2.5 onboard buses were created with and without control for roadway concentrations, which were also modeled. Predictors examined included ambient PM2.5 levels, ambient weather, and
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
drug for the treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] > /= 5 years of age) were followed-up after treatment with injectable artesunate for severe [...] patients. A decrease in Hb levels between 2 and 5 g/dL was detected in 23 (11.4%) patients during the follow-up period. For five patients, Hb levels decreased below 5 g/dL during at least one follow-up visit
Long-term exposure to air pollution and chronic kidney disease-associated mortality - results from the pooled cohort of the European multicentre... (Publications)
Associations were positive for PM(2.5) (hazard ratio (HR) with 95% confidence interval (CI) of 1.31 (1.03-1.66) per 5μg/m(3), BC (1.26 (1.03-1.53) per 0.5×10(- 5)/m), NO(2) (1.13 (0.93-1.38) per 10μg/m(3)) [...] dioxide (NO(2)), black carbon (BC), ozone (O(3)), particulate matter ≤2.5μm (PM(2.5)) and several elemental constituents of PM(2.5). Cox regression models were adjusted for age, sex, cohort, calendar year