Design, synthesis, and <em>in vitro</em> cancer cell growth inhibition evaluation of troxianes installed in cyclic 2-enoate substructure (Publications)
human cancer cell lines. Compounds 5k, 5l, 5s, 7a and 7c exhibited the highest activity and selectivity against a human leukemia (MV4-11) cell line (IC50 = 0.5 ?M). Compound 5o showed the highest growth factor
Multiple myeloma risk in relation to long-term air pollution exposure: a pooled analysis of four European cohorts (Publications)
confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO(2), 1.04 (0.82, 1.33) per 5 μg/m³ PM(2.5), 0.99 (0.84, 1.18) per 0.5 10(-5) m(-1) BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O(3). CONCLUSIONS: We did not [...] assessed the association between residential exposure to nitrogen dioxide (NO(2)), fine particles (PM(2.5)), black carbon (BC), and ozone (O(3)) and multiple myeloma. We applied Cox proportional hazards models
Design, synthesis, and <em>in vitro</em> cancer cell growth inhibition evaluation of troxianes installed in cyclic 2-enoate substructure (Publications)
human cancer cell lines. Compounds 5k, 5l, 5s, 7a and 7c exhibited the highest activity and selectivity against a human leukemia (MV4-11) cell line (IC50 = 0.5 ?M). Compound 5o showed the highest growth factor
Assessment of diabetes and prediabetes prevalence and predictors by HbA1c in a population from sub-Saharan Africa with a high proportion of anemia: a... (Publications)
were 6.8% (95% CI 5.3 to 8.5) and 25% (95% CI 22.8 to 28.3), respectively. There was an increase in DM prevalence in patients 50-59 (14.9%; 95% CI 9.1 to 22.5), > /=60 years old (18.5%; 95% CI 12.2 to 26 [...] 26.2) and in patients with overweight (9.3%; 95% CI 5.9 to 13.7), obesity (10.9%; 95% CI 6.9 to 16) compared with patients 18-29 years old (2.2%; 95% CI 0.9 to 4.4) (p
Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana <em>ancistrocladus ealaensis </em>with... (Publications)
constitutionally unsymmetric dimers, each consisting of two 5,8'-coupled naphthylisoquinoline monomers. While the molecular halves of michellamine A5 (2) are linked via C-6' of both of the naphthalene moieties [...] Four new dimeric naphthylisoquinoline alkaloids, michellamine A5 (2) and mbandakamines C-E (4-6), were isolated from the Congolese plant Ancistrocladus ealaensis, along with the known dimer mbandakamine [...] axis is located in one of the peri-positions, neighboring one of the outer...
Body weight changes in people living with HIV starting dolutegravir versus efavirenz-based regimens in a large cohort in rural Tanzania (Publications)
(26.3%) overweight/obese; 621 (51.5%) initiated efavirenz-based and 584 (48.5%) dolutegravir-based ART. After 18 months, estimated weight gain was 5.1 kg (95%CI 4.7-5.5) in the dolutegravir versus 4.0 kg
Multiple myeloma risk in relation to long-term air pollution exposure: a pooled analysis of four European cohorts (Publications)
confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO(2), 1.04 (0.82, 1.33) per 5 μg/m³ PM(2.5), 0.99 (0.84, 1.18) per 0.5 10(-5) m(-1) BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O(3). CONCLUSIONS: We did not [...] assessed the association between residential exposure to nitrogen dioxide (NO(2)), fine particles (PM(2.5)), black carbon (BC), and ozone (O(3)) and multiple myeloma. We applied Cox proportional hazards models
A profile of travelers - an analysis from a large Swiss travel clinic (Publications)
Tourism was the main reason for travel (17,875, 81.5%), followed by visiting friends and relatives (VFRs; 1,715, 7.8%), traveling for business (1,223, 5.6%), and "other reasons" (ie, volunteer work, pilgrimage [...] women (23, 3.9%) were observed. Mental disorders were more prominent in VFRs (93, 5.4%) and in travel for "other reasons" (63, 5.7%). The latter stayed for the longest periods abroad; 272 (24.9%) stayed longer [...] pilgrimage, study abroad, and emigration; 1,112, 5.1%). The main...
Prenatal air pollution exposure and early cardiovascular phenotypes in young adults (Publications)
analysis. Prenatal PM10 and PM2.5 exposures were associated with increased CAS. For example, a 2 SD increase in prenatal PM2.5 was associated with CAS indices, including a 5% increase (beta = 1.05, 95% CI [...] beta, a 5% increase (beta = 1.05, 95% CI 1.01-1.10) in Young's elastic modulus and a 5% decrease (beta = 0.95, 95% CI 0.91-0.99) in distensibility. Mutually adjusted models of pre- and postnatal PM2.5 further
A household-based community health worker programme for non-communicable disease, malnutrition, tuberculosis, HIV and maternal health: a stepped-wedge... (Publications)
interval: -2.5 to 0.5)) while maintaining the already low default rates for HIV patients (0.0 pp, 95% CI: -0.6 to 0.5). First trimester ANC attendance increased by approximately 30% (6.5pp (-0.3, 15.8)) [...] facilities. The intervention roll-out was staggered every 3 months over 18 months, with CHWs receiving a 5-day foundational training for their new tasks and assigned 20-40 households for monthly (or more frequent) [...] 8)) and paediatric malnutrition case finding declined by 10% (-0.6 per...