Long-term exposure to low-level PM2.5 and mortality: investigation of heterogeneity by harmonizing analyses in large cohort studies in Canada, United... (Publications)
BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter
Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric... (Publications)
concentration alone. We therefore investigated the association of UADT and gastric cancers with PM(2.5) elemental constituents and sources components indicative of different sources within a large multicentre [...] confounders. We observed 1139 UADT and 872 gastric cancer cases during a mean follow-up of 18.3 and 18.5 years, respectively. UADT cancer incidence was associated with all constituents except K in single element
Methodological manual for air pollution health risk assessments in Switzerland: deliverable 5 of the project QHIAS (Quantification of health impact of... (Publications)
international and Swiss literature on this field has been reviewed. This report concluded that PM2.5 or PM10 (PM2.5/PM10) as well as NO2 and O3 are the most suitable air pollution indicators for AP-HRAs in S
Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles (Publications)
The 4-substituted 3-amino-1,2,5-oxadiazole 1 from the Malaria Box Project of the Medicines for Malaria Venture foundation shows very promising selectivity and in vitro activity against Plasmodium falciparum [...] determined experimentally (CYP3A4-inhibition and aqueous solubility). N-[4-(3-ethoxy-4-methoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methylbenzamide 51 showed high in vitro activity against the chloroquine-sensitive
Culture and psychiatric evaluation: operationalizing cultural formulation for DSM-5 (Publications)
guidance on implementation, training, and application in diverse settings. To address this need, DSM-5 introduced a cultural formulation interview (CFI) that operationalizes the process of data collection [...] article summarizes the literature reviews and analyses of experience with the OCF conducted by the DSM-5 Cross-Cultural Issues Subgroup (DCCIS) that informed the development of the CFI. We review the history
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, there prodrugs and aza-analogues (Publications)
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC50 values below 25nM against Trypanosoma brucei [...] for efficacy in mice infected with T. b. rhodesiense STIB900. Six diamidines cured 4/4 mice at daily 5mg/kg intraperitoneal doses for 4days, giving results far superior to pentamidine and furamidine. One
Acute-phase proteins and mortality in status epilepticus: a 5-year observational cohort study (Publications)
OBJECTIVE: Acute-phase proteins, such as C-reactive protein and albumin, may be related with course and outcome in status epilepticus, as changes of cytokine levels and blood-brain barrier breakdown d
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of... (Publications)
Replacement of the pyridine core of antimalarial 3,5-diaryl-2-aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other changes [...] core and replacement or substitution of the 2-amino group led to loss of antimalarial activity. The 3,5-diaryl-2-aminopyrazine series showed impressive in vitro antiplasmodial activity against the K1 (multidrug
Re-estimated equations for 5th percentiles of lung function variables (Letter to editors) (Publications)
applied extrapolations of the 5th percentile curves to men aged between 60 and 70 years2 and have found that for some of the lung function parameters---for example, FEV1---the 5th percentiles appeared to get [...] In 1996 we published reference equations for the 5th percentiles of lung function parameters (FVC, FEV1, PEF, FEF25, FEF50, FEF75, FEF25-75, FEV1/FVC) as a function of age and height.1 These reference