Antitrypanosomal sesquiterpene lactones from <em>Saussurea costus</em> (Publications)
lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC(50)s between 0.8 and 22muM. Cytotoxic IC(50)s were from 1.6 to 19muM, and selectivity indices from 0.5 to 6.5
Premature mortality due to air pollution in European cities: a health impact assessment (Publications)
mug/m(3) for PM2.5 and 40 mug/m(3) for NO2) were achieved and if air pollution concentrations were reduced to the lowest values measured in 2015 in European cities (ie, 3.7 mug/m(3) for PM2.5 and 3.5 mug/m(3) [...] deaths per 100 000 population for PM2.5 and from 0 to 73 deaths for NO2 per 100 000 population when the lowest measured concentrations were considered. The highest PM2.5 mortality burden was estimated for [...] e health impact assessment for the year 2015 to estimate the effect of air...
Premature mortality due to air pollution in European cities: a health impact assessment (Publications)
mug/m(3) for PM2.5 and 40 mug/m(3) for NO2) were achieved and if air pollution concentrations were reduced to the lowest values measured in 2015 in European cities (ie, 3.7 mug/m(3) for PM2.5 and 3.5 mug/m(3) [...] deaths per 100 000 population for PM2.5 and from 0 to 73 deaths for NO2 per 100 000 population when the lowest measured concentrations were considered. The highest PM2.5 mortality burden was estimated for [...] e health impact assessment for the year 2015 to estimate the effect of air...
Association between air pollution and rhinitis incidence in two European cohorts (Publications)
increase of 5mug.m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10mug.m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5mug.m(-3) of [...] (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the [...] of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional...
Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)
involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) kappabeta pathway) and GNG5P5, respectively. Single nucleotide polymorphisms [...] polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p = 9.96x10-9). The second replication phase, in seven independent cohorts, provided no significant
Chronic bronchitis and urban air pollution in an international study (Publications)
prevalence and new onset of chronic phlegm during the follow-up were 6.9% and 4.5%, respectively, in males and 5.3% and 3.5% in females. Smoking, rhinitis, poor education and low social class showed associations [...] follow- from the years 2000 to 2002 (n = 3232 males and 3592 females; average response rate = 65.3%). PM2.5 and elements, with the same equipment at centre level, and home outdoor NO2 in 1,634 individuals were [...] 77) as well as home outdoor NO2 (OR > 50 ig/m3 versus < 20 ig3 =...
Arginine and lysine transporters are essential for <em>Trypanosoma brucei</em> (Publications)
high affinity (Km 4.3 +/- 0.5 muM) and highly selective L-lysine transporter and of the compounds tested, only L-lysine and thialysine were competing for L-lysine uptake. TbAAT5-3 and TbAAT16-1 are expressed [...] plasma membrane. RNAi-mediated down-regulation of TbAAT5 and TbAAT16 in bloodstream form trypanosomes resulted in growth arrest, demonstrating that TbAAT5-mediated arginine and TbAAT16-mediated lysine transport [...] amino acid transporters among members of the T. brucei AAAP (amino...
Microsatellite and mitochondrial genetic differentiation of <em>Anopheles arabiensis</em> (Diptera: Culicidae) from western Kenya, the Great Rift... (Publications)
investigated using 12 microsatellite loci and a partial sequence of mtDNA dehydrogenase gene subunit 5 (ND5). The mean number of alleles and the observed heterozygosity were similar for the mosquito populations [...] the three regions as revealed by the microsatellite data. A total of 30 polymorphic sites in the ND5 gene defined 39 haplotypes. Six haplotypes were shared among four populations from the three distinct [...] markers outside inversions (F(ST) = 0.016) or inside fixed inversions...
Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)
involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) kappabeta pathway) and GNG5P5, respectively. Single nucleotide polymorphisms [...] polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p = 9.96x10-9). The second replication phase, in seven independent cohorts, provided no significant
Association between air pollution and rhinitis incidence in two European cohorts (Publications)
increase of 5mug.m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10mug.m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5mug.m(-3) of [...] (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the [...] of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional...