Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)
involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) kappabeta pathway) and GNG5P5, respectively. Single nucleotide polymorphisms [...] polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p = 9.96x10-9). The second replication phase, in seven independent cohorts, provided no significant
Association between air pollution and rhinitis incidence in two European cohorts (Publications)
increase of 5mug.m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10mug.m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5mug.m(-3) of [...] (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the [...] of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional...
Arginine and lysine transporters are essential for <em>Trypanosoma brucei</em> (Publications)
high affinity (Km 4.3 +/- 0.5 muM) and highly selective L-lysine transporter and of the compounds tested, only L-lysine and thialysine were competing for L-lysine uptake. TbAAT5-3 and TbAAT16-1 are expressed [...] plasma membrane. RNAi-mediated down-regulation of TbAAT5 and TbAAT16 in bloodstream form trypanosomes resulted in growth arrest, demonstrating that TbAAT5-mediated arginine and TbAAT16-mediated lysine transport [...] amino acid transporters among members of the T. brucei AAAP (amino...
Lignans, amides, and saponins from <em>Haplophyllum tuberculatum</em> and their antiprotozoal activity (Publications)
loyltyramine (5), (E)-N-feruloyltyramine (6), N,N'-diferuloylputrescine (8), and 7'-ethoxy-feruloyltyramine (9). The water fraction yielded steroid saponins 11-13. Compounds 1, 2, and 5-13 are reported [...] Nectandrin B (2) exhibited the highest activity against L. donovani (IC50 4.5 microM) and the highest selectivity index (25.5).
Lignans, amides, and saponins from <em>Haplophyllum tuberculatum</em> and their antiprotozoal activity (Publications)
loyltyramine (5), (E)-N-feruloyltyramine (6), N,N'-diferuloylputrescine (8), and 7'-ethoxy-feruloyltyramine (9). The water fraction yielded steroid saponins 11-13. Compounds 1, 2, and 5-13 are reported [...] Nectandrin B (2) exhibited the highest activity against L. donovani (IC50 4.5 microM) and the highest selectivity index (25.5).
A prospective evaluation of the diagnostic accuracy of the point-of-care VISITECT CD4 Advanced Disease test in seven countries (Publications)
301-500, and > 500 cells/µl, VISITECT misclassified 4.5% (95% CI 2.5-7.2%), 12.5 (95% CI 8.0-18.2%), 74.1% (95% CI 67.0-80.5%), 48.0% (95% CI 42.5-53.6%), and 22.6% (95% CI 19.3-26.3%), respectively. [...] RESULTS: Among 1604 participants, the median flow cytometry CD4 was 367 (IQR 128-626) cells/µl and 521 (32.5%) had a CD4 ≤200 cells/µl. VISITECT sensitivity was 92.7% (483/521, 95% CI 90.1-94.7%) and specificity
Efficacy and safety of a single-dose mebendazole 500 mg chewable, rapidly-disintegrating tablet for <em>Ascaris lumbricoides</em> and <em>Trichuris... (Publications)
lumbricoides (97.9% [95% CI: 94.4; 99.9] versus 19.2% [95% CI: -5.9; 41.5]; P < 0.001) and T. trichiura (59.7% [95% CI: 33.9; 78.8] versus 10.5% [95% CI: -16.8; 32.9]; P = 0.003). Treatment-emergent adverse [...] 74.2%; 90.8%] versus 11.1% [9/81; 95% CI: 5.2%; 20.1%], P < 0.001) and for T. trichiura (33.9% [42/124; 95% CI: 25.6%; 42.9%] versus 7.6% [9/119; 95% CI: 3.5%; 13.9%], P < 0.001). Egg reduction rates [...] adverse events (TEAEs) in MBZ group occurred in 6.3% (9/144) of patients during...
Cardiorespiratory hospitalisation and mortality reductions after smoking bans in Switzerland (Publications)
detected in ischaemic heart disease hospitalisations, with a 2.5% reduction (95% confidence interval [CI)] -6.2 to 1.3%) for all ages and 5.5% (95% CI -10.8 to -0.2%) in adults 35-64 years old. Total mortality [...] post-ban reductions in mortality due to hypertensive disorders (-5.4%, 95% CI -12.6 to 2.3%), and congestive heart failure (-6.0%, 95% CI -14.5 to 3.4%). No benefits were observed for hospitalisations due [...] all ages, and chronic obstructive pulmonary disease mortality decreased...
Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide... (Publications)
BACKGROUND: Fine particulate matter (PM(2.5)) is a well-recognized risk factor for premature death. However, evidence on which PM(2.5) components are most relevant is unclear. METHODS: We evaluated the [...] the associations between mortality and long-term exposure to eight PM(2.5) elemental components [copper (Cu), iron (Fe), zinc (Zn), sulfur (S), nickel (Ni), vanadium (V), silicon (Si), and potassium (K)] [...] regression models at a 100 x 100 m scale to estimate the residential annual mean...
Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide... (Publications)
BACKGROUND: Fine particulate matter (PM(2.5)) is a well-recognized risk factor for premature death. However, evidence on which PM(2.5) components are most relevant is unclear. METHODS: We evaluated the [...] the associations between mortality and long-term exposure to eight PM(2.5) elemental components [copper (Cu), iron (Fe), zinc (Zn), sulfur (S), nickel (Ni), vanadium (V), silicon (Si), and potassium (K)] [...] regression models at a 100 x 100 m scale to estimate the residential annual mean...
