<em>ent</em>-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the... (Publications)
1'-coupled ent-dioncophylleine A (3a), the likewise 7,1'-coupled 5'-O-demethyl-ent-dioncophylleine A (4), and the 7,8'-linked dioncophylleine D (5), have been isolated from the leaves of the recently described [...] only axially chiral, naphthylisoquinoline alkaloids of this type that are optically active; compound 5, by contrast, is fully racemic, due to its configurationally unstable biaryl axis. The structural e
Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant <em>Ancistrocladus... (Publications)
dimeric naphthylisoquinoline alkaloids, shuangancistrotectorines A (3 a), B (3 b), C (4), D (5 a), and E (5 b), have been isolated from the twigs of the Chinese plant Ancistrocladus tectorius. Their absolute [...] in total. Some of the compounds, in particular shuangancistrotectorines A, B, and D (3 a, 3 b, and 5 a) exhibit very good, and specific, antiplasmodial activities
Diagnostic accuracy of the InBios Scrub Typhus DetectTM ELISA for the detection of IgM antibodies in Chittagong, Bangladesh (Publications)
of 91.5 (95% confidence interval (95% CI: 96.8(-)82.5) and a specificity (Sp) of 92.4 (95% CI: 95.0(-)89.0), while for convalescent samples the OD cut-off was > /=1.50 with Sn of 66.0 (95% CI: 78.5(-)51 [...] admission samples, the best Sn/Sp compromise was at 1.25 OD (Sn 91.5%, Sp 92.4%) and for convalescent samples at 0.75 OD (Sn 69.8%, Sp 89.5%). A relatively high (stringent) diagnostic cut-off value provides
Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, Spain (Publications)
we investigated the association between three independent size fractions, coarse (PM10-2.5), intermodal (PM2.5-1), and very fine PMs (PM1), and three health outcomes, respiratory, cardiovascular, and [...] PM10-2.5 was 1.059 (95% CI, 1.026-1.094) for cardiovascular mortality and 1.098 (95% CI, 1.030-1.171) for cerebrovascular mortality. Association with respiratory mortality was only detected for PM2.5-1 at [...] from different sources and the mechanisms of action. We found that increased...
Premature mortality of epilepsy in low- and middle-income countries: a systematic review from the mortality task force of the International League... (Publications)
mortality ratio (PMR) of 27.3% (range 5-75.5%) derived from population-based studies. These direct causes comprise status epilepticus, with reported PMRs ranging from 5 to 56.6%, and sudden unexpected death [...] studies yielded 7.1 (range 1.6-25.1) deaths per 1,000 people. The weighted median SMRs were 5.0 in male and 4.5 in female patients; relatively higher SMRs within studies were measured in children and adolescents
Evaluation of giant African pouched rats for detection of pulmonary tuberculosis in patients from a high-endemic setting (Publications)
sensitivity of 56.9% (95% CI 47.0-66.3), specificity of 80.5% (95% CI 72.5-86.9), positive and negative predictive value of 71.3% (95% CI 60.6-80.5) and 68.7% (95% CI 60.6-76.0), and an accuracy for TB diagnosis [...] molecular confirmation of Mycobacterium tuberculosis, and by clinical data at enrolment and for at least 5-months of follow-up to determine the reference standard. Seven trained giant African pouched rats were [...] for Mycobacterium tuberculosis and 128 (27.3%) were non-TB...
Helminth infections and risk factor analysis among residents in Eryuan county, Yunnan province, China (Publications)
Trichuris trichiura and hookworms was 15.4%, 3.5%, 1.7% and 0.3%, respectively. The seroprevalence of Trichinella spp. was 58.8% and that of cysticercosis 18.5%. The egg positivity rate of S. japonicum in [...] China, including risk factor analysis. We collected stool and blood samples from 3220 individuals, aged 5-88 years, from 35 randomly selected villages in Eryuan county, Yunnan province, China. Stool samples [...] in the 13 known endemic villages was 2.7%, and the corresponding...
Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with... (Publications)
rate. We aimed to show non-inferiority (with a margin of -5%) of dispersible versus crushed tablet. We constructed an asymptotic one-sided 97.5% CI on the difference in cure rates. A computer-generated [...] 3-99.2) in the group on dispersible formulation and 98.5% (97.4-99.7) in the group on crushed formulation. The lower bound of the one-sided 97.5% CI was -2.7%. The most common drug-related adverse event [...] with uncomplicated malaria. METHODS: We did a randomised non-inferiority study on...
Research on the dynamic characteristics of indoor and outdoor environmental quality of office buildings based on long-term online monitoring of... (Publications)
summer > spring > autumn > winter, while the rank of indoor PM2.5 is winter > spring > autumn > summer. However, the outdoor humidity, outdoor PM2.5 and indoor and outdoor illumination, formaldehyde TVOC and [...] and variation characteristics of temperature, humidity, illumination, formaldehyde, TVOC, CO2 and PM2.5 in different floors of 6th, 9th, and 15th at different time scales. The results show that:① for the [...] then decreasing. In contrast, illumination shows a trend of first decreasing...
Comparison of two different semiquantitative urinary dipstick tests with albumin-to-creatinine ratio for screening and classification of albuminuria... (Publications)
Sensitivity was 82.9% (95% CI 75.1-89.1%) and 91.9% (95% CI 88.7-96.9%) and specificity 71.5% (95% CI 68.4-74.6%) and 17.5% (95% CI 15.0-20.2%) for the Combur9-Test((R)) and Micral-Test((R)), respectively. Correct [...] cut-offs of 30, 100, and > /=300 mg/dL, and with the Micral-Test((R)) it was 1.8%, 10.5%, and 53.6% at cut-offs of 2, 5, and 10 mg/dL, respectively. Overall, disagreement to KDIGO albuminuria was seen in [...] and 73% with the Combur9-Test((R)) and Micral-Test((R)), respectively....