Premature mortality of epilepsy in low- and middle-income countries: a systematic review from the mortality task force of the International League... (Publications)
mortality ratio (PMR) of 27.3% (range 5-75.5%) derived from population-based studies. These direct causes comprise status epilepticus, with reported PMRs ranging from 5 to 56.6%, and sudden unexpected death [...] studies yielded 7.1 (range 1.6-25.1) deaths per 1,000 people. The weighted median SMRs were 5.0 in male and 4.5 in female patients; relatively higher SMRs within studies were measured in children and adolescents
Evaluation of giant African pouched rats for detection of pulmonary tuberculosis in patients from a high-endemic setting (Publications)
sensitivity of 56.9% (95% CI 47.0-66.3), specificity of 80.5% (95% CI 72.5-86.9), positive and negative predictive value of 71.3% (95% CI 60.6-80.5) and 68.7% (95% CI 60.6-76.0), and an accuracy for TB diagnosis [...] molecular confirmation of Mycobacterium tuberculosis, and by clinical data at enrolment and for at least 5-months of follow-up to determine the reference standard. Seven trained giant African pouched rats were [...] for Mycobacterium tuberculosis and 128 (27.3%) were non-TB...
Comparison of two different semiquantitative urinary dipstick tests with albumin-to-creatinine ratio for screening and classification of albuminuria... (Publications)
Sensitivity was 82.9% (95% CI 75.1-89.1%) and 91.9% (95% CI 88.7-96.9%) and specificity 71.5% (95% CI 68.4-74.6%) and 17.5% (95% CI 15.0-20.2%) for the Combur9-Test((R)) and Micral-Test((R)), respectively. Correct [...] cut-offs of 30, 100, and > /=300 mg/dL, and with the Micral-Test((R)) it was 1.8%, 10.5%, and 53.6% at cut-offs of 2, 5, and 10 mg/dL, respectively. Overall, disagreement to KDIGO albuminuria was seen in [...] and 73% with the Combur9-Test((R)) and Micral-Test((R)), respectively....
Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, Spain (Publications)
we investigated the association between three independent size fractions, coarse (PM10-2.5), intermodal (PM2.5-1), and very fine PMs (PM1), and three health outcomes, respiratory, cardiovascular, and [...] PM10-2.5 was 1.059 (95% CI, 1.026-1.094) for cardiovascular mortality and 1.098 (95% CI, 1.030-1.171) for cerebrovascular mortality. Association with respiratory mortality was only detected for PM2.5-1 at [...] from different sources and the mechanisms of action. We found that increased...
Residential proximity to major roads and term low birth weight: the roles of air pollution, heat, noise, and road-adjacent trees (Publications)
term low birth weight (LBW), while exploring possible mediating roles of air pollution (PM2.5, PM2.5-10, PM10, PM2.5 absorbance, nitrogen dioxide, and nitrogen oxides), heat, and noise and buffering effect [...] interquartile range increase in heat exposure with an 18% increase; and third-trimester exposure to PM2.5, PM2.5-10, and PM10 with 24%, 25%, and 26% increases, respectively. Air pollution and heat exposures together
Research on the dynamic characteristics of indoor and outdoor environmental quality of office buildings based on long-term online monitoring of... (Publications)
summer > spring > autumn > winter, while the rank of indoor PM2.5 is winter > spring > autumn > summer. However, the outdoor humidity, outdoor PM2.5 and indoor and outdoor illumination, formaldehyde TVOC and [...] and variation characteristics of temperature, humidity, illumination, formaldehyde, TVOC, CO2 and PM2.5 in different floors of 6th, 9th, and 15th at different time scales. The results show that:① for the [...] then decreasing. In contrast, illumination shows a trend of first decreasing...
Diagnostic accuracy of the InBios Scrub Typhus DetectTM ELISA for the detection of IgM antibodies in Chittagong, Bangladesh (Publications)
of 91.5 (95% confidence interval (95% CI: 96.8(-)82.5) and a specificity (Sp) of 92.4 (95% CI: 95.0(-)89.0), while for convalescent samples the OD cut-off was > /=1.50 with Sn of 66.0 (95% CI: 78.5(-)51 [...] admission samples, the best Sn/Sp compromise was at 1.25 OD (Sn 91.5%, Sp 92.4%) and for convalescent samples at 0.75 OD (Sn 69.8%, Sp 89.5%). A relatively high (stringent) diagnostic cut-off value provides
PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults (Publications)
responses to circumsporozoite surface protein (PfCSP) and merozoite surface protein 5 (PfMSP5). We show that PfMSP5 is detectable on the surface and in the apical complex of PfSPZ. INTERPRETATION: Our [...] affect the quantity of the total IgG and IgM antibody responses to PfCSP and PfMSP5 after immunization with PfSPZ Vaccine. PfMSP5 represents a highly immunogenic, so far underexplored, target for vaccine-induced
Influence of exposure assessment methods on associations between long-term exposure to outdoor fine particulate matter and risk of cancer in the... (Publications)
(1.19-1.73) for one IQR increase of cumulative PM2.5 exposure for the LUR and the Gazel-Air models respectively, followed by a plateau at around 1.5 for both exposure assessments. For lung cancer (349 [...] BACKGROUND: Many studies investigated the relationship between outdoor fine particulate matter (PM2.5) and cancer. While they generally indicated positive associations, results have not been fully consistent [...] the diversity of methods used to assess exposure. OBJECTIVES: To investigate...
Mutual effects of fine particulate matter, nitrogen dioxide, and fireworks on cause-specific acute cardiovascular mortality: a case-crossover study in... (Publications)
mortality of traffic-related air pollutants such as nitrogen dioxide (NO2) and fine particulate matter (PM2.5) are still debated. We conducted a time-stratified case-crossover study for a population located around [...] We estimated the risk of cause-specific cardiovascular mortality associated with daily NO2 and PM2.5 concentrations at home using distributed lag models up to 7 days preceding death, adjusted for daily [...] , and holidays. Cardiovascular mortality was associated with NO2,...