Exposure of highway maintenance workers to fine particulate matter and noise (Publications)
particulate matter (PM2.5), particle number concentration (PNC), noise (Leq), and the gaseous co-pollutants: carbon monoxide, nitrogen dioxide, and ozone. Mean work shift PM2.5 concentrations (gravimetric [...] paving and guardrail repair. We found moderate Spearman correlations between PNC and PM2.5 (r = 0.56); PNC, PM2.5, and CO (r = 0.60 and r = 0.50) as well as PNC and noise (r = 0.50). Variability and correlation [...] s) ranged from 20.3 to 321 mug m(-3) (mean 62 mug m(-3)) and PNC were...
Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and... (Publications)
Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10mum (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major [...] the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% CI: 0.93-1.47), and S in PM2.5 (1.08, 95% CI: 0.95-1.22) and PM10 (1.09, 95% CI: 0.90-1.32). CONCLUSION: In [...] We found no statistically significant associations between any of the...
Understanding diarrhoeal diseases in response to climate variability and drought in Cape Town, South Africa: a mixed methods approach (Publications)
decreased over the decade studied, e.g. reduction of 64.7% in 2019 [95% confidence interval (CI): 5.5-7.2%] compared to 2010, with no increase during the severe drought period. Over the hot dry diarrhoeal [...] diarrhoea with dehydration incidence increased by 7.4% (95% CI: 4.5-10.3%) per 1 °C increase in temperature and 2.6% (95% CI: 1.7-3.5%) per 1% increase in relative humidity in the unlagged model. Stakeholder [...] METHODS: Using a mixed-methods approach, we explored diarrhoeal disease...
Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe (Publications)
from different exposure domains: air pollution (nitrogen dioxide (NO(2)), particulate matter < 2.5 mum (PM(2.5)), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) and [...] was associated with an increase in stroke incidence. The first PC of the air pollution domain (PM(2.5), NO(2) and BC) was associated with an increase in stroke incidence. For the built environment, higher [...] impervious surfaces were associated with a protective effect [%change in HR...
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas (Publications)
survival rate (mean follow-up 7.5+/-4.8 years) was highest for patients with oligodendroglioma (78% at 5 years, 51% at 10 years), followed by those with oligoastrocytoma (70% at 5 years, 49% at 10 years) and [...] and fibrillary astrocytoma (65% at 5 years, 31% at 10 years). Survival of patients with gemistocytic astrocytoma was poor, with survival rates of 16% at 5 years and 0% at 10 years. Younger patients ( 50
Skin and soft tissue infections in intercontinental travellers and the import of multi-resistant <em>Staphylococcus aureus</em> to Europe (Publications)
and associated with travel to South Asia (ORcrude 5.3, 95% CI 2.4-11.8), even after adjusting for confounding by genotype (ORadjusted 3.8, 95% 1.5-9.5). Choosing randomly from compounds recommended for [...] (PVL) positive. PVL was associated with disease severity, including hospitalization for SSTI (OR 5.2, 95% CI 1.5-18.2). In returnees with SSTI, longer travel and more intense population contact were risk factors
Particulate matter air pollution components and risk for lung cancer (Publications)
residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m3), PM10 Zn (1.28; 1.02-1.59 per 20ng/m3), PM10 S (1.58; 1.03-2.44 per 200ng/m3) [...] 33 per 100ng/m3). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. CONCLUSIONS: This study indicates that the association between PM in air [...] land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and...
Association of environmental tobacco smoke at work and forced expiratory lung function among never smoking asthmatics and non-asthmatics. The... (Publications)
or FEF25-75% (-1.9%; -4.2 to +0.5). Effects were observed among asthmatics (n = 325), FEV1 (-4.8%; 0 to -9.2); FEF25-75% (-12.4%; -3.7 to -20.4); FVC: (-1.7%; +2.1 to -5.5), particularly in asthmatic women [...] women (n = 183): FVC -4.4% (-9.6 to +1.1); FEV1: -8.7% (-14.5 to -2.5); FEF25-75%: -20.8% (-32 to -7.6), where duration of ETS exposure at work was associated with lung function (FEV1 -6% per hour of ETS
A randomized clinical trial to identify the optimal antigen and MF59((R)) adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy... (Publications)
priming dose of MF59-adjuvanted A/H1N1 vaccine provided healthy adult (3.75mug or 7.5mug formulations) and healthy elderly (7.5mug formulation) individuals with adequate levels of seroprotection. Booster ad [...] healthy elderly (> 60 years) participants. Subjects received vaccine containing either 3.75mug or 7.5mug antigen, adjuvanted with half the standard dose, or a standard dose of MF59((R)) (Novartis Vaccines) [...] investigated were highly immunogenic and well tolerated in both adult and...
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas (Publications)
survival rate (mean follow-up 7.5+/-4.8 years) was highest for patients with oligodendroglioma (78% at 5 years, 51% at 10 years), followed by those with oligoastrocytoma (70% at 5 years, 49% at 10 years) and [...] and fibrillary astrocytoma (65% at 5 years, 31% at 10 years). Survival of patients with gemistocytic astrocytoma was poor, with survival rates of 16% at 5 years and 0% at 10 years. Younger patients ( 50