A randomized clinical trial to identify the optimal antigen and MF59((R)) adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy... (Publications)
priming dose of MF59-adjuvanted A/H1N1 vaccine provided healthy adult (3.75mug or 7.5mug formulations) and healthy elderly (7.5mug formulation) individuals with adequate levels of seroprotection. Booster ad [...] healthy elderly (> 60 years) participants. Subjects received vaccine containing either 3.75mug or 7.5mug antigen, adjuvanted with half the standard dose, or a standard dose of MF59((R)) (Novartis Vaccines) [...] investigated were highly immunogenic and well tolerated in both adult and...
Exposure of highway maintenance workers to fine particulate matter and noise (Publications)
particulate matter (PM2.5), particle number concentration (PNC), noise (Leq), and the gaseous co-pollutants: carbon monoxide, nitrogen dioxide, and ozone. Mean work shift PM2.5 concentrations (gravimetric [...] paving and guardrail repair. We found moderate Spearman correlations between PNC and PM2.5 (r = 0.56); PNC, PM2.5, and CO (r = 0.60 and r = 0.50) as well as PNC and noise (r = 0.50). Variability and correlation [...] s) ranged from 20.3 to 321 mug m(-3) (mean 62 mug m(-3)) and PNC were...
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas (Publications)
survival rate (mean follow-up 7.5+/-4.8 years) was highest for patients with oligodendroglioma (78% at 5 years, 51% at 10 years), followed by those with oligoastrocytoma (70% at 5 years, 49% at 10 years) and [...] and fibrillary astrocytoma (65% at 5 years, 31% at 10 years). Survival of patients with gemistocytic astrocytoma was poor, with survival rates of 16% at 5 years and 0% at 10 years. Younger patients ( 50
A randomized clinical trial to identify the optimal antigen and MF59((R)) adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy... (Publications)
priming dose of MF59-adjuvanted A/H1N1 vaccine provided healthy adult (3.75mug or 7.5mug formulations) and healthy elderly (7.5mug formulation) individuals with adequate levels of seroprotection. Booster ad [...] healthy elderly (> 60 years) participants. Subjects received vaccine containing either 3.75mug or 7.5mug antigen, adjuvanted with half the standard dose, or a standard dose of MF59((R)) (Novartis Vaccines) [...] investigated were highly immunogenic and well tolerated in both adult and...
Association of environmental tobacco smoke at work and forced expiratory lung function among never smoking asthmatics and non-asthmatics. The... (Publications)
or FEF25-75% (-1.9%; -4.2 to +0.5). Effects were observed among asthmatics (n = 325), FEV1 (-4.8%; 0 to -9.2); FEF25-75% (-12.4%; -3.7 to -20.4); FVC: (-1.7%; +2.1 to -5.5), particularly in asthmatic women [...] women (n = 183): FVC -4.4% (-9.6 to +1.1); FEV1: -8.7% (-14.5 to -2.5); FEF25-75%: -20.8% (-32 to -7.6), where duration of ETS exposure at work was associated with lung function (FEV1 -6% per hour of ETS
Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and... (Publications)
Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10mum (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major [...] the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% CI: 0.93-1.47), and S in PM2.5 (1.08, 95% CI: 0.95-1.22) and PM10 (1.09, 95% CI: 0.90-1.32). CONCLUSION: In [...] We found no statistically significant associations between any of the...
Understanding diarrhoeal diseases in response to climate variability and drought in Cape Town, South Africa: a mixed methods approach (Publications)
decreased over the decade studied, e.g. reduction of 64.7% in 2019 [95% confidence interval (CI): 5.5-7.2%] compared to 2010, with no increase during the severe drought period. Over the hot dry diarrhoeal [...] diarrhoea with dehydration incidence increased by 7.4% (95% CI: 4.5-10.3%) per 1 °C increase in temperature and 2.6% (95% CI: 1.7-3.5%) per 1% increase in relative humidity in the unlagged model. Stakeholder [...] METHODS: Using a mixed-methods approach, we explored diarrhoeal disease...
Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe (Publications)
from different exposure domains: air pollution (nitrogen dioxide (NO(2)), particulate matter < 2.5 mum (PM(2.5)), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) and [...] was associated with an increase in stroke incidence. The first PC of the air pollution domain (PM(2.5), NO(2) and BC) was associated with an increase in stroke incidence. For the built environment, higher [...] impervious surfaces were associated with a protective effect [%change in HR...
Ambient air pollution and hypertensive disorders of pregnancy in Rome (Publications)
were used to estimate the exposure to particulate matter (PM(2.5) and PM(10)), nitrogen dioxide (NO(2)), and ozone (O(3)). RESULTS: For PM(2.5,) PM(10) and NO(2), there was suggestive evidence of increased [...] hypertension (GH, n = 1901). For instance, an interquartile range of 7.0 μg/m(3) increase in PM(2.5) exposure during the first trimester of pregnancy was associated with an odds ratio (OR) of 1.06 (95% [...] NO(2) and the corresponding results for a 15.7 μg/m(3) increase in NO(2) after...
Schistosomiasis status and health impact in preschool-aged children in hard-to-reach areas and populations of Homa Bay County, Kenya (Publications)
moderate (8.5 %) and heavy infections (2.2 %). Significantly increased odds for infection were observed in children aged four (aOR = 4.4, 95 % CI: 1.7-11.2) and five years (aOR = 5.6, 95 % CI: 2.2-14.5), in girls [...] populations of Homa Bay County, Kenya. A cross-sectional study was conducted among 476 PSAC aged 2-5 years across 6 islands in Lake Victoria, Homa Bay County, Kenya. Kato-Katz and urine filtration techniques [...] girls (aOR = 2.5, 95 % CI: 1.3-4.8), and in children living in...