Diaryl ureas as an antiprotozoal chemotype (Publications)
potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models
Diaryl ureas as an antiprotozoal chemotype (Publications)
potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models
Reprint of "Epidemiology of brucellosis, Q fever and Rift Valley fever at the human and livestock interface in northern Côte d'Ivoire" (Publications)
Brucella spp. was 5.3%. RBPT-positive small ruminants tested negative by the indirect ELISA. The seroprevalence of Brucella spp. in cattle adjusted for clustering was 4.6%. Cattle aged 5-8 years had higher [...] higher odds of seropositivity (OR=3.5) than those aged
Comparison of light scattering devices and impactors for particulate measurements in indoor, outdoor, and personal environments (Publications)
fractionation inlet) against measurements from both Harvard impactors (HI2.5) and Harvard personal environmental monitors (HPEM2.5) for PM2.5 in indoor, outdoor, and personal settings. These measurements were
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides (Publications)
N(1)-Phenyl-3,5-dinitro-N(4),N(4)-di-n-propylsulfanilamide (1) and N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites [...] potent compounds are rapidly degraded by rat liver S9 fractions in vitro, N(1)-(3-hydroxy)phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (21) displays an IC(50) value of 260nM against African tr
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides (Publications)
N(1)-Phenyl-3,5-dinitro-N(4),N(4)-di-n-propylsulfanilamide (1) and N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites [...] potent compounds are rapidly degraded by rat liver S9 fractions in vitro, N(1)-(3-hydroxy)phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (21) displays an IC(50) value of 260nM against African tr
Comparison of light scattering devices and impactors for particulate measurements in indoor, outdoor, and personal environments (Publications)
fractionation inlet) against measurements from both Harvard impactors (HI2.5) and Harvard personal environmental monitors (HPEM2.5) for PM2.5 in indoor, outdoor, and personal settings. These measurements were
Reprint of "Epidemiology of brucellosis, Q fever and Rift Valley fever at the human and livestock interface in northern Côte d'Ivoire" (Publications)
Brucella spp. was 5.3%. RBPT-positive small ruminants tested negative by the indirect ELISA. The seroprevalence of Brucella spp. in cattle adjusted for clustering was 4.6%. Cattle aged 5-8 years had higher [...] higher odds of seropositivity (OR=3.5) than those aged
Global, regional, and national burden of mortality associated with short-term temperature variability from 2000-19: a three-stage modelling study (Publications)
associated with temperature variability, global gridded temperature data with a resolution of 0.5 degrees x 0.5 degrees were used to assess the temperature variability-related mortality burden at the global [...] assess the global temperature variability-related mortality burden at a spatial resolution of 0.5 degrees x 0.5 degrees from 2000-19. Temperature variability was calculated as the SD of the average of the [...] mortality increased by about 4.6% (3.7-5.3) per decade. The largest increase...
Modelling the relationship between malaria prevalence as a measure of transmission and mortality across age groups (Publications)
from aggregated data over 4 to 5-year periods, which is the typical period that mortality data are available from national demographic and health surveys. RESULTS: Using 5-year aggregated data, associations [...] mortality across age groups over 4 to 5 year periods with clinical malaria more strongly associated with mortality than parasite prevalence. This effect was stronger in children 5-14 years compared to other age-groups [...] prevalence (PP) and clinical malaria (parasites plus reported...