Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
with promising activity: N(6)-benzyl-5'-N-phenylcarboxamidoadenosine with an IC(50) value of 0.91muM against Trypanosoma brucei rhodesiense and N(6)-diphenylethyl-5'-phenylcarboxamidoadenosine with an IC(50) [...] speed up the process of lead finding and we pursued the solid-phase synthesis of di- and trisubstituted 5'-carboxamidoadenosine derivatives by using a safety-catch approach. While efforts with Kenner's sulfonamide
<em>Plasmodium falciparum</em> protein kinase 5 and the malarial nuclear division cycles (Publications)
from our proposition that PfPK5 is necessary to activate or maintain the parasite S-phase. Immunolocalization studies provide further evidence for this potential role of PfPK5 [...] Plasmodium falciparum, we investigated expression pattern, kinase activity, and localization of PfPK5, a putative malarial member of the family of cyclin-dependent protein kinase (cdks). The kinase was [...] from parasites blocked with the cell-cycle inhibitor aphidicolin. An elevated kinase activity of PfPK5 from...
The first population structure and comparative genomics analysis of <em>Mycobacterium africanum</em> strains from Ghana reveals higher diversity of... (Publications)
within a single cluster of L5 strains from Southern Ghana isolated in 2013. Among the global collection of MTB complex, there were four Ghana-specific L5 clusters of which one (L5.1.1) had traits of clonal [...] and 93 L5) of the genomes were de novo assembled and annotated for comparative pangenome analysis using Roary. RESULTS: The population structure of MAF revealed at least five clusters of L5 as compared [...] using whole genome sequencing. METHODS: Clinical MTB complex strains (n=187)...
European Community Respiratory Health Survey II : final report of work package 6 : PM2.5 assessment in 21 European cities of ECRHS II (Publications)
of the centres varies if PM2.5 mass concentrations are considered season by season and examines the association of NO2 with PM2.5 in the participating centres. Since PM2.5 is not routinely monitored in [...] present the annual mean PM2.5 mass concentrations in the participating centres and to describe the methodology and the European-wide quality control programme for the collection of PM2.5 in the ECRHS II. Furthermore [...] in Europe, we measured PM2.5 mass concentrations in 21 participating...
Feasibility, acceptability and clinical utility of the cultural formulation interview: mixed-methods results from the DSM-5 international field trial (Publications)
diagnostic assessment. AIMS: To assess the feasibility, acceptability and clinical utility of the DSM-5 Cultural Formulation Interview (CFI) in routine clinical practice. METHOD: Mixed-methods evaluation [...] significantly and subsequent interviews required less time. CONCLUSIONS: The CFI was included in DSM-5 as a feasible, acceptable and useful cultural assessment tool.
Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data (Publications)
estimates of PM2.5 and NO2 are increasingly used in combination with Land Use Regression (LUR) models. We aimed to compare the contribution of SAT and CTM data to the performance of LUR PM2.5 and NO2 models [...] monitoring data sets: PM2.5 and NO2 ground level measurements from the European Study of Cohorts for Air Pollution Effects (ESCAPE) and from the European AIRBASE network. LUR PM2.5 models including SAT and [...] and SAT+CTM explained ~60% of spatial variation in measured PM2.5...
Geostatistical modelling of malaria indicator survey data to assess the effects of interventions on the geographical distribution of malaria... (Publications)
representative survey conducted to provide estimates of malaria prevalence among children less than 5 years, and to track the progress of control interventions in the country. In this present study, 2014-15 [...] were analysed to assess intervention effects on malaria prevalence in Uganda among children less than 5 years, assess intervention effects at regional level, and estimate geographical distribution of malaria [...] status and higher level of mother's education. The highest prevalence of...