Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: beyond mortality from cardiopulmonary disease... (Publications)
exposure to PM2.5 (mean: 12.4 microg/m(3)), NO2 (20.3 microg/m(3)), and/or BC (1.0 x 10(-5)/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 microg/m(3) increase [...] from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide [...] increase in PM2.5 was associated with higher mortality from...
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo
Representative seroprevalences of human and livestock brucellosis in two Mongolian provinces (Publications)
was 27.3% in humans (95% CI 23.7-31.2%), 6.2% (95% CI 5.5-7.1%) in sheep, 5.2% (95% CI 4.4-5.9%) in goats, 16.0% (95% CI 13.7-18.7%) in cattle, 2.5% (95% CI 0.8-7.6%) in camels, 8.3 (95% CI 6.0-11.6%) in
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample (Publications)
carefully defined significance threshold of 1.3x10(-5). The most significant loci associated with FEV(1) include SNPs tagging MACROD2 (P = 6.81x10(-5)), CNTN5 (P = 4.37x10(-4)), and TRPV4 (P = 1.58x10(-3)) [...] with FEV(1) (P = 8.41x10(-5)), followed by PDE4D (P = 1.22x10(-4)). The strongest association with FEV(1)/FVC ratio was observed with ABCC1 (P = 4.38x10(-4)), and ESR1 (P = 5.42x10(-4)) among ever-smokers
Socio-environmental factors associated with the risk of contracting Buruli ulcer in Tiassalé, south Côte d'Ivoire: a case-control study (Publications)
(male:female) was 0.9. Median age was 25 years (range: 5-70 years). Regular contact with unprotected surface water (adjusted odds ratio (aOR) = 6.5; 95% confidence interval (CI) = 2.1-19.7) and absence [...] absence of protective equipment during agricultural activities (aOR = 18.5, 95% CI = 5.2-66.7) were identified as the main factors associated with the risk of contracting BU. Etiologic fractions among exposed [...] health centers of the district. Two controls were matched for each control,...
Physical activity intensity and surrogate markers for cardiovascular health in adolescents (Publications)
high) based on the daily time spent in moderate-to-vigorous PA (MVPA, 3,000-5,200 counts(.)min(-1), model 1) and vigorous PA (VPA, > 5,200 counts(.)min(-1), model 2). MVPA was an independent predictor for rMSSD [...] = 0.046). In model 2, the high VPA group had higher maximum power output values (3.9 +/- 0.5 vs. 3.4 +/- 0.5 W kg(-1), P = 0.012). In both models, no significant differences were observed for RHI and [Formula: [...] surrogate markers of cardiovascular health in adolescents. 52...
Evaluation and quality control of personal nephelometers in indoor, outdoor and personal environments (Publications)
as well as at a central site. All fixed-site pDRs were collocated with Harvard Impactors for PM2.5 (HI2.5). By examining the differences between the time-weighted average concentrations calculated from [...] suffered from negative drifts. By comparing the pDRs' daily base level with the HI2.5 measurements, we identified 5.7% of the pDRs' measurements suffered from positive drifts. High relative humidity (RH) [...] ts to remove the RH effect. The final R2 values between the fixed-site pDRs and...
Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against <em>Haemophilus... (Publications)
pathway (C5) on both effector functions. Findings may be relevant for the treatment of certain diseases caused by dysregulation of the complement system, where inhibitors of complement factors C3 or C5 are used [...] vaccination significantly enhanced SBA titers. Independently of the vaccination status, both C3 and C5 inhibition abrogated SBA, whereas inhibition of the LP had no effect. AP inhibition had a major inhibitory [...] unmasked when bacterial killing by the membrane attack complex was...
Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping <em>Mycobacterium tuberculosis</em> complex isolates in Ghana (Publications)
MTBC in Ghana. METHOD: One hundred and fifty-eight MTBC isolates classified into Lineage 4 and Lineage 5 were used to compare a customized lineage-specific panel of 12 MIRU-VNTR loci ("customized MIRU-12'') [...] Index (HGDI). A minimal set of customized MIRU-VNTR loci for typing Lineages 4 (Euro-American) and 5 (M. africanum West African 1) strains from Ghana was defined based on the cumulative HGDI. RESULTS AND [...] genotypes, including 1 cluster of 2 isolates (clustering rate: 0.9%) and 104...