Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors (Publications)
at work OR 5.33, (1.57-18.0), OR 3.37 (1.04-10.87). Poultry farmers experienced the highest symptom rates. In crop farmers, the prevalence for chronic bronchitis was increased OR 2.32 (1.03-5.23). Over [...] (0.99-5.4) independent of the type of farming. The comparison of Swiss farmers with the Swiss population showed a twofold elevated risk of reporting chronic bronchitis OR 1.89 (1.32-2.95) and a 4.5-fold [...] 5-fold elevated risk for bringing up phlegm regularly OR 4.5 (3.25-6.69) in...
Physical activity intensity and surrogate markers for cardiovascular health in adolescents (Publications)
high) based on the daily time spent in moderate-to-vigorous PA (MVPA, 3,000-5,200 counts(.)min(-1), model 1) and vigorous PA (VPA, > 5,200 counts(.)min(-1), model 2). MVPA was an independent predictor for rMSSD [...] = 0.046). In model 2, the high VPA group had higher maximum power output values (3.9 +/- 0.5 vs. 3.4 +/- 0.5 W kg(-1), P = 0.012). In both models, no significant differences were observed for RHI and [Formula: [...] surrogate markers of cardiovascular health in adolescents. 52...
Evaluation and quality control of personal nephelometers in indoor, outdoor and personal environments (Publications)
as well as at a central site. All fixed-site pDRs were collocated with Harvard Impactors for PM2.5 (HI2.5). By examining the differences between the time-weighted average concentrations calculated from [...] suffered from negative drifts. By comparing the pDRs' daily base level with the HI2.5 measurements, we identified 5.7% of the pDRs' measurements suffered from positive drifts. High relative humidity (RH) [...] ts to remove the RH effect. The final R2 values between the fixed-site pDRs and...
Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping <em>Mycobacterium tuberculosis</em> complex isolates in Ghana (Publications)
MTBC in Ghana. METHOD: One hundred and fifty-eight MTBC isolates classified into Lineage 4 and Lineage 5 were used to compare a customized lineage-specific panel of 12 MIRU-VNTR loci ("customized MIRU-12'') [...] Index (HGDI). A minimal set of customized MIRU-VNTR loci for typing Lineages 4 (Euro-American) and 5 (M. africanum West African 1) strains from Ghana was defined based on the cumulative HGDI. RESULTS AND [...] genotypes, including 1 cluster of 2 isolates (clustering rate: 0.9%) and 104...
Representative seroprevalences of human and livestock brucellosis in two Mongolian provinces (Publications)
was 27.3% in humans (95% CI 23.7-31.2%), 6.2% (95% CI 5.5-7.1%) in sheep, 5.2% (95% CI 4.4-5.9%) in goats, 16.0% (95% CI 13.7-18.7%) in cattle, 2.5% (95% CI 0.8-7.6%) in camels, 8.3 (95% CI 6.0-11.6%) in
Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against <em>Haemophilus... (Publications)
pathway (C5) on both effector functions. Findings may be relevant for the treatment of certain diseases caused by dysregulation of the complement system, where inhibitors of complement factors C3 or C5 are used [...] vaccination significantly enhanced SBA titers. Independently of the vaccination status, both C3 and C5 inhibition abrogated SBA, whereas inhibition of the LP had no effect. AP inhibition had a major inhibitory [...] unmasked when bacterial killing by the membrane attack complex was...
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample (Publications)
carefully defined significance threshold of 1.3x10(-5). The most significant loci associated with FEV(1) include SNPs tagging MACROD2 (P = 6.81x10(-5)), CNTN5 (P = 4.37x10(-4)), and TRPV4 (P = 1.58x10(-3)) [...] with FEV(1) (P = 8.41x10(-5)), followed by PDE4D (P = 1.22x10(-4)). The strongest association with FEV(1)/FVC ratio was observed with ABCC1 (P = 4.38x10(-4)), and ESR1 (P = 5.42x10(-4)) among ever-smokers
Socio-environmental factors associated with the risk of contracting Buruli ulcer in Tiassalé, south Côte d'Ivoire: a case-control study (Publications)
(male:female) was 0.9. Median age was 25 years (range: 5-70 years). Regular contact with unprotected surface water (adjusted odds ratio (aOR) = 6.5; 95% confidence interval (CI) = 2.1-19.7) and absence [...] absence of protective equipment during agricultural activities (aOR = 18.5, 95% CI = 5.2-66.7) were identified as the main factors associated with the risk of contracting BU. Etiologic fractions among exposed [...] health centers of the district. Two controls were matched for each control,...
MOSASWA Modelling Support (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mosaswa-modelling-support
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High prevalence of <em>Schistosoma haematobium</em> x <em>Schistosoma bovis</em> hybrids in schoolchildren in Côte d'Ivoire (Publications)
15 S. haematobium sequences (45.5%) belonging to seven haplotypes and 18 S. bovis sequences (54.5%) belonging to 12 haplotypes. Of 40 ITS 2 sequences analysed, 31 (77.5%) were assigned to pure S. haematobium [...] haematobium, four (10.0%) to pure S. bovis and five (12.5%) to S. haematobium-bovis hybrids. Our findings suggest that S. haematobium-bovis hybrids are common in Cote d'Ivoire. Hence, intense prospection of