Enantiospecific antitrypanosomal<em> in vitro</em> activity of eflornithine (Publications)
concentrations of the three strains combined were 9.1 muM (95% confidence interval [8.1; 10]), 5.5 muM [4.5; 6.6], and 50 muM [42; 57] for racemic eflornithine, L-eflornithine and D-eflornithine, respectively
Long-term exposure to black carbon and mortality: a 28-year follow-up of the GAZEL cohort (Publications)
adjusting for individual and area-level covariates. To handle confounding by PM2.5, we used the residual of BC regressed on PM2.5 as an alternate exposure variable. For all-cause mortality, we also examined [...] and 2017. Land use regression model with temporal extrapolation wa used to estimate yearly BC and PM2.5 exposure at the residential addresses from 1989 until censoring for 19,906 participants. Time-varying
Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years (Publications)
z-transformed EP latencies (s-EPT0) and other baseline variables with EDSST5. RESULTS: We found that s-EPT0 correlated with EDSST5 (rho=0.72, p [...] resonance imaging (MRI) scan at T0 and T2. EDSS testing was repeated at year 14 (T4) and year 20 (T5). Spearman rank correlation was used. We performed a multivariable regression analysis to examine predictive
Spraying tick-infested houses with lambda-cyhalothrin reduces the incidence of tick-borne relapsing fever in children under five years old (Publications)
spraying with lambda-cyhalothrin on domestic tick infestation and the incidence of TBRF in children under 5 years old. Two neighbouring villages were studied: one was sprayed with insecticide, the other left [...] The incidence of TBRF was estimated by microscopy of thick blood films taken from all children under 5 years old presenting with fever to the village dispensary or health workers. After 2 cycles of spraying [...] numbers remained high. In the treated village there were 29 cases of TBRF...
Antitrypanosomal cycloartane glycosides from Astragalus baibutensis (Publications)
with acetylastragaloside I (1) being the most potent (IC50 9.5 microg/ml). Acetylastragaloside I (1) was also lethal to T. cruzi (IC50 5.0 microg/ml), and it is the first cycloartane-type triterpene with [...] Baibutoside (5), a new cycloartane-type triterpene glycoside, has been isolated from the roots of Astragalus baibutensis along with four known glycosides, acetylastragaloside I (1), and astragalosides
Spraying tick-infested houses with lambda-cyhalothrin reduces the incidence of tick-borne relapsing fever in children under five years old (Publications)
spraying with lambda-cyhalothrin on domestic tick infestation and the incidence of TBRF in children under 5 years old. Two neighbouring villages were studied: one was sprayed with insecticide, the other left [...] The incidence of TBRF was estimated by microscopy of thick blood films taken from all children under 5 years old presenting with fever to the village dispensary or health workers. After 2 cycles of spraying [...] numbers remained high. In the treated village there were 29 cases of TBRF...
Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years (Publications)
z-transformed EP latencies (s-EPT0) and other baseline variables with EDSST5. RESULTS: We found that s-EPT0 correlated with EDSST5 (rho=0.72, p [...] resonance imaging (MRI) scan at T0 and T2. EDSS testing was repeated at year 14 (T4) and year 20 (T5). Spearman rank correlation was used. We performed a multivariable regression analysis to examine predictive
Clonorchicidal properties of the synthetic trioxolane OZ78 (Publications)
mu g/ml of OZ78. A single 300 mg/kg oral dose of OZ78 resulted in worm burden reductions of 78.5% and 98.5% against juvenile and adult C. sinensis, respectively. SEM observations revealed tegumental surface [...] activity against another liver fluke, namely Clonorchis sinensis. Rats infected with C. sinensis for 2 and 5 wk were treated orally with single doses of OZ78 (75, 150, or 300 mg/kg). Worm burden reductions were
Clonorchicidal properties of the synthetic trioxolane OZ78 (Publications)
mu g/ml of OZ78. A single 300 mg/kg oral dose of OZ78 resulted in worm burden reductions of 78.5% and 98.5% against juvenile and adult C. sinensis, respectively. SEM observations revealed tegumental surface [...] activity against another liver fluke, namely Clonorchis sinensis. Rats infected with C. sinensis for 2 and 5 wk were treated orally with single doses of OZ78 (75, 150, or 300 mg/kg). Worm burden reductions were
Increase of dose associated with decrease in protection against controlled human malaria infection by PfSPZ vaccine in Tanzanian adults (Publications)
All 22 CHMIs in controls resulted in parasitemia by qPCR. For the 9x105 PfSPZ group, VE was 100% (5/5) at 3 or 11 weeks (p [...] experienced 6-month to 65-year-olds in the U.S., Europe, and Africa. When vaccine efficacy (VE) of 5 doses of 2.7x105 PfSPZ of PfSPZ Vaccine was assessed in adults against controlled human malaria infection