Long-term exposure to black carbon and mortality: a 28-year follow-up of the GAZEL cohort (Publications)
adjusting for individual and area-level covariates. To handle confounding by PM2.5, we used the residual of BC regressed on PM2.5 as an alternate exposure variable. For all-cause mortality, we also examined [...] and 2017. Land use regression model with temporal extrapolation wa used to estimate yearly BC and PM2.5 exposure at the residential addresses from 1989 until censoring for 19,906 participants. Time-varying
Enantiospecific antitrypanosomal<em> in vitro</em> activity of eflornithine (Publications)
concentrations of the three strains combined were 9.1 muM (95% confidence interval [8.1; 10]), 5.5 muM [4.5; 6.6], and 50 muM [42; 57] for racemic eflornithine, L-eflornithine and D-eflornithine, respectively
Ambient air pollution exposure and depressive symptoms: findings from the French CONSTANCES cohort (Publications)
mean concentration of PM(2.5), BC and NO(2) were 17.14 microg/m(3) (IQR = 4.89), 1.82 10(-5)/m (IQR = 0.88) and 26.58 microg/m(3) (IQR = 17.41) respectively. Exposures to PM(2.5), BC and NO(2) were significantly [...] analyzed cross-sectionally. Annual concentrations of particulate matter with a diameter < 2.5 microm (PM(2.5)), black carbon (BC), and nitrogen dioxide (NO(2)) from the land-use regression models were
Ambient air pollution exposure and depressive symptoms: findings from the French CONSTANCES cohort (Publications)
mean concentration of PM(2.5), BC and NO(2) were 17.14 microg/m(3) (IQR = 4.89), 1.82 10(-5)/m (IQR = 0.88) and 26.58 microg/m(3) (IQR = 17.41) respectively. Exposures to PM(2.5), BC and NO(2) were significantly [...] analyzed cross-sectionally. Annual concentrations of particulate matter with a diameter < 2.5 microm (PM(2.5)), black carbon (BC), and nitrogen dioxide (NO(2)) from the land-use regression models were
Long-term exposure to ambient air pollution and risk of lung cancer: a comparative analysis of incidence and mortality in four administrative cohorts... (Publications)
respective meta-analytic HRs (95% CIs) of 1.14 (1.06, 1.22) and 1.12 (1.02, 1.22) per 5 μg/m(3) increase in PM(2.5), and 1.10 (1.04, 1.16) and 1.09 (1.02, 1.16) per 10 μg/m(3) increase in NO(2). Positive [...] Rome (2001-2015). We assessed residential exposure to annual average fine particulate matter (PM(2.5)), nitrogen dioxide (NO₂), black carbon (BC), and warm-season ozone (O(3)) using Europe-wide land use [...] 111,949 incident lung cancer cases occurred. Incident lung cancer was positively...
Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI (Publications)
diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a-c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines [...] vitro against the protozoan parasite Trypanosoma brucei rhodesiense (T. b. r.). The thiophene analogue 5b and the N-methyl compound 15a showed superior antitrypanosomal activity compared to that of the parent
Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI (Publications)
diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a-c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines [...] vitro against the protozoan parasite Trypanosoma brucei rhodesiense (T. b. r.). The thiophene analogue 5b and the N-methyl compound 15a showed superior antitrypanosomal activity compared to that of the parent
Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the... (Publications)
based on the 2·5th and 97·5th percentile of draws that were carried through the multistage computational framework. FINDINGS: Global age-standardised smoking prevalence was estimated to be 28·5% (95% UI 27·9-29·1) [...] 27·9-29·1) among males and 5·96% (5·76-6·21) among females in 2022. In the reference scenario, smoking prevalence declined by 25·9% (25·2-26·6) among males, and 30·0% (26·1-32·1) among females from 2022 [...] scenario provides estimates for countries considering policies to...
Physical fitness and nutritional anthropometric status of children from disadvantaged communities in the Nelson Mandela Bay region (Publications)
children had normal weight (76.7%), while 4.5% were underweight and 18.7% were overweight/obese. Underweight children and children with stunted growth (11.5%) had lower average upper body strength (p [...] communities in the Nelson Mandela Bay region. Methods: Nine hundred and sixty-five children (49% girls, M=9.5 years) participated in this cross-sectional study. Height and weight were measured to establish body
The exit interview as a proxy measure of malaria case management practice: sensitivity and specificity relative to direct observation (Publications)
trained research officer as part of a repeat cross sectional survey. Patient recall of 5 forms of clinical advice and 5 forms of clinical action were then assessed at service exit and statistical analyses [...] exit interviews with respect to clinical advice ranged from 36.2% to 96.4% and specificity from 53.5% to 98.6%. With respect to clinical actions, sensitivity of the exit interviews ranged from 83.9% to