A Mitogen-activated protein kinase controls differentiation of bloodstream forms of <em>Trypanosoma brucei</em> (Publications)
by complementation with wild-type TbMAPK5 but exacerbated by introduction of a nonactivatable mutant form. Our results indicate a regulatory function for TbMAPK5 in the differentiation of bloodstream forms [...] tsetse fly vector. To characterize the role of a mitogen-activated protein (MAP) kinase homologue, TbMAPK5, in the differentiation of Trypanosoma brucei, we constructed a knockout in procyclic (insect) forms
Physical fitness and nutritional anthropometric status of children from disadvantaged communities in the Nelson Mandela Bay region (Publications)
children had normal weight (76.7%), while 4.5% were underweight and 18.7% were overweight/obese. Underweight children and children with stunted growth (11.5%) had lower average upper body strength (p [...] communities in the Nelson Mandela Bay region. Methods: Nine hundred and sixty-five children (49% girls, M=9.5 years) participated in this cross-sectional study. Height and weight were measured to establish body
A Mitogen-activated protein kinase controls differentiation of bloodstream forms of <em>Trypanosoma brucei</em> (Publications)
by complementation with wild-type TbMAPK5 but exacerbated by introduction of a nonactivatable mutant form. Our results indicate a regulatory function for TbMAPK5 in the differentiation of bloodstream forms [...] tsetse fly vector. To characterize the role of a mitogen-activated protein (MAP) kinase homologue, TbMAPK5, in the differentiation of Trypanosoma brucei, we constructed a knockout in procyclic (insect) forms
The exit interview as a proxy measure of malaria case management practice: sensitivity and specificity relative to direct observation (Publications)
trained research officer as part of a repeat cross sectional survey. Patient recall of 5 forms of clinical advice and 5 forms of clinical action were then assessed at service exit and statistical analyses [...] exit interviews with respect to clinical advice ranged from 36.2% to 96.4% and specificity from 53.5% to 98.6%. With respect to clinical actions, sensitivity of the exit interviews ranged from 83.9% to
Risk factors for new infection with Leptospira in meat workers in New Zealand (Publications)
and hide removal; relative risk, RR 7.5, 95% CI 2.5 to 22.4), followed by positions on the line involving the removal of high-risk material (bladder, and kidneys; RR 5.2, 95% CI 1.7 to 16.0). Risk was lower [...] against either serovar. While in sheep meat workers, the annual infection risk was 11.3% (95% CI 8.5% to 14.8%), in deer meat workers it was 0% (95% CI 0.0% to 10.9%) and in those processing beef cattle
Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study (Publications)
in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0mL (13.6, 72.5), 49.5mL (20.1, 78.8) and 49.7mL (18.6, 80 [...] conducted separately for never- and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations ( 75th percentile (high)). RESULTS: Among current smokers, physical
Increase in airway obstruction between 1993 and 2012 in Switzerland: an observational study (Publications)
prevalence increased between 1993 and 2012 from 6.1% (95% CI: 5.5 to 6.7) to 15.6% (95% CI: 13.8 to 17.3) based on GLI, and from 5.3% (95% CI: 4.7 to 5.9) to 15.4% (95% CI: 13.6 to 17.1) based on Hankinson estimates
Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity (Publications)
2%) and non-allergic rhinitis 323 (5.5%). The risk of allergic rhinitis was increased in subjects with physician diagnosed asthma (Relative Risk Ratio 6.81; 95%CI 5.39, 8.6), maternal atopy (1.56; 1.27 [...] of non-allergic rhinitis was also increased in subjects with physician diagnosed asthma (4.02; 2.86, 5.67), reduced in males (0.59; 0.46, 0.77), but not associated with upbringing on a farm or older siblings
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. II. Mortality and morbidity (Publications)
plus Plasmodium falciparum (Pf) parasitaemia > or = 10,000 parasites/microliters blood were 5%, 4.1% and 1.5%, respectively. The corresponding figures for adults were 2%, 0.9% and 0.1%, respectively. The [...] 49 deaths assessed through medical records. Malaria was the first cause of death in children aged 0.5-4 years. Of the 7795 subjects interviewed and bled during six cross-sectional community-based surveys [...] aged 1-4 years and adults older than 19 years and of > or = 10,000...
Suicidality and sexual orientation among men in Switzerland: findings from 3 probability surveys (Publications)
highest 12-month prevalences for suicidal ideation (35.4%) and suicide attempts (11.5%) and the lowest attempt ratios (1:1.5 for attempt to plan and 1:3.1 for attempt to ideation). The lifetime prevalence [...] of suicide attempts among homo/bisexual men aged 16-20 years varies from 5.1% in ch-x to 14.1% in SMASH to 22.0% in GGMHS. Compared to their heterosexual counterparts, significantly more homo/bisexual [...] attempts (OR = 2.09-2.26) and lifetime suicidal ideation (OR = 2.15) and suicide...