Anilinoquinoline based inhibitors of trypanosomatid proliferation (Publications)
We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this
Fetal growth, stillbirth, infant mortality and other birth outcomes near UK municipal waste incinerators; retrospective population based cohort and... (Publications)
BACKGROUND: Some studies have reported associations between municipal waste incinerator (MWI) exposures and adverse birth outcomes but there are few studies of modern MWIs operating to current Europea
Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development (Publications)
Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recogn
Dynamics of respiratory symptoms during infancy and associations with wheezing at school age (Publications)
Children with frequent respiratory symptoms in infancy have an increased risk for later wheezing, but the association with symptom dynamics is unknown. We developed an observer-independent method to c
Translating preventive chemotherapy prevalence thresholds for <em>Schistosoma mansoni </em>from the Kato-Katz technique into the point-of-care... (Publications)
BACKGROUND: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. T