Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors (Publications)
A series of aryl nitrile-based ligands were prepared to investigate the effect of their electrophilicity on the affinity against the cysteine proteases rhodesain and human cathepsin L. Density functio
Vitamin D supplementation in Swiss infants (Publications)
BACKGROUND: Various recent publications reported clinical manifestations of vitamin D deficiency in infants. Furthermore new research revealed additional properties of vitamin D for bone health and in
Independent contribution of parental migrant status and educational level to adiposity and eating habits in preschool children (Publications)
BACKGROUND/OBJECTIVE: Little is known about the precise role of parental migrant status (MS) and educational level (EL) on adiposity and various eating habits in young children. Therefore, we assessed
Treatment with human growth hormone in patients with Prader-Labhart-Willi syndrome reduces body fat and increases muscle mass and physical performance (Publications)
Twelve children with documented Prader-Labhart-Willi syndrome were treated with human growth hormone (24 U/m2/week) during 1 year. The children were divided into three groups: group 1: overweight and
Eating habits of preschool children with high migrant status in Switzerland according to a new food frequency questionnaire (Publications)
Assessment of eating habits in young children from multicultural backgrounds has seldom been conducted. Our objectives were to study the reproducibility and the results of a food frequency questionnai
Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities (Publications)
Trypanothione reductase (TR) is an essential enzyme in the trypanothione-based redox metabolism of trypanosomatid parasites. This system is absent in humans and, therefore, offers a promising target f