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1. Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model (Publications)

   Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model

   Relevance:

   We perform sensitivity analyses on a mathematical model of malaria transmission to determine the relative importance of model parameters to disease transmission and prevalence. We compile two sets of

2. Chemotherapeutic development strategies for schistosomiasis (Publications)

   Chemotherapeutic development strategies for schistosomiasis

   Relevance:

3. Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma (Publications)

   Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma

   Relevance:

   OBJECTIVE: To investigate HIV-related immunodeficiency as a risk factor for hepatocellular carcinoma (HCC) among persons infected with HIV, while controlling for the effect of frequent coinfection wit

4. Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-Saharan Africa (Publications)

   Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-Saharan Africa

   Relevance:

   OBJECTIVE: To develop a decision-support tool to help policy-makers in sub-Saharan Africa assess whether intermittent preventive treatment in infants (IPTi) would be effective for local malaria contro

5. Un protocole simplifié pour l'évaluation des pratiques et des coûts de la lutte antivectorielle faite à l'échelon individuel et familial (Publications)

   Un protocole simplifié pour l'évaluation des pratiques et des coûts de la lutte antivectorielle faite à l'échelon individuel et familial

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6. Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase (Publications)

   Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase

   Relevance:

   Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were evaluated. Some of our compounds inhibit

7. Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin (Publications)

   Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin

   Relevance:

   Chemical investigation of the marine sponge Plakortis cfr. lita afforded a library of endoperoxyketal polyketides, manadoperoxides B-K (3-5 and 7-13) and peroxyplakoric esters B(3) (6) and C (14). Eig

8. Bifurcation analysis of a mathematical model for malaria transmission (Publications)

   Bifurcation analysis of a mathematical model for malaria transmission

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9. The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore (Publications)

   The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore

   Relevance:

   Cyclin D1 (CCND1), an intracellular cell-cycle regulatory protein with checkpoint function, can promote cell proliferation or induce growth arrest and apoptosis depending on the cellular context. We h

10. Whole-genome sequencing of rifampicin-resistant <em>Mycobacterium tuberculosis</em> strains identifies compensatory mutations in RNA polymerase genes (Publications)

    Whole-genome sequencing of rifampicin-resistant <em>Mycobacterium tuberculosis</em> strains identifies compensatory mutations in RNA polymerase genes

    Relevance:

    Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that t