How to bring research evidence into policy? Synthesizing strategies of five research projects in low-and middle-income countries (Publications)
BACKGROUND: Addressing the uptake of research findings into policy-making is increasingly important for researchers who ultimately seek to contribute to improved health outcomes. The aims of the Swiss
Durchgängiger Strategieprozess als Erfolgsfaktor einer exzellenten Organisation (Publications)
Das Generieren von neuem Wissen zu drängenden Fragen der öffentlichen Gesundheit, deren Umsetzung und Skalierung sind ressourcenintensive Tätigkeiten, die nicht alleine über kompetitive Forschungsgeld
The pharmacokinetics and drug-drug interactions of ivermectin in <em>Aedes aegypti</em> mosquitoes (Publications)
Mosquitoes are vectors of major diseases such as dengue fever and malaria. Mass drug administration of endectocides to humans and livestock is a promising complementary approach to current insecticide
Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action (Publications)
Leucinostatin A is one of the most potent antiprotozoal compounds ever described, but little was known on structure-activity relationships (SAR). We used Trypanosoma brucei as a protozoal model organi
A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: is it time to... (Publications)
BACKGROUND: Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less
Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a (Publications)
Limited therapeutic options are available for the treatment of human schistosomiasis caused by the parasitic Schistosoma flatworm. The B cell lymphoma-2 (BCL-2)-regulated apoptotic cell death pathway
Quest for a potent antimalarial drug lead: synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines (Publications)
Quinazolines have long been known to exert varied pharmacologic activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, we have synthesi
Parasite-host dynamics throughout antimalarial drug development stages complicate the translation of parasite clearance (Publications)
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes pre-clinical murine and experimental human malaria infection studies to ev
