Natural polymorphisms in <em>Mycobacterium tuberculosis </em>conferring resistance to delamanid in drug-naïve patients (Publications)
Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for suc
Trypanosomes have divergent kinesin-2 proteins that function differentially in flagellum biosynthesis and cell viability (Publications)
Trypanosoma brucei, the causative agent of African sleeping sickness, has a flagellum that is crucial for motility, pathogenicity, and viability. In most eukaryotes, the intraflagellar transport (IFT)
Communities and clinical trials: a case study from the RTS,S malaria vaccine trials in eastern Africa (Publications)
When clinical trials enter human communities, two complex systems merge-creating challenges for the clinical trial team and the local human community. This is of particular relevance for clinical tria
Mobile pastoralists in Africa: a blind spot in global health surveillance (Publications)
Mobile pastoralists subsist primarily on herds of livestock such as camels, cattle, and goats, migrating seasonally to access water and grazing areas. Speculative estimates of their global population
Breastfeeding following<em> in vitro</em> fertilisation in Switzerland - does mode of conception affect breastfeeding behaviour? (Publications)
AIM: Breastfeeding has numerous advantages. Our aim was to investigate whether breastfeeding initiation and duration in women with pregnancies conceived through in vitro fertilisation differ from spon
Patterns of pesticide usage in agriculture in rural Tanzania call for integrating agricultural and public health practices in managing... (Publications)
BACKGROUND: Unrestricted use of pesticides in agriculture is likely to increase insecticide resistance in mosquito vectors. Unfortunately, strategies for managing insecticide resistance in agriculture
PfMAP-2 is essential for male gametogenesis in the malaria parasite<em> Plasmodium falciparum</em> (Publications)
In malaria parasites, male gametogenesis is a proliferative stage essential for parasite transmission to the mosquito vector. It is a rapid process involving three rounds of genome replication alterna
Naturally occurring cardenolides affecting <em>Schistosoma mansoni</em> (Publications)
Schistosomiasis is a neglected tropical disease of considerable public health burden. We recently discovered a micromolar activity of several cardenolides against newly transformed schistosomula (NTS)
