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1. Introduction (Publications)

   Introduction

   Relevance:

   The geographical focus of this book pertains to Europe and Central Asia, while thematically, the seven chapters concentrate on a group of diseases, collec tively termed neglected tropical diseases (NT

2. Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations (Publications)

   Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

   Relevance:

   Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in po

3. Neglected tropical diseases - Europe and Central Asia (Publications)

   Neglected tropical diseases - Europe and Central Asia

   Relevance:

4. R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with <em>Schistosoma mansoni</em> and... (Publications)

   R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with <em>Schistosoma mansoni</em> and <em>S. haematobium</em> and Lao adults infected with <em>Opisthorchis viverrini</em>

   Relevance:

   Racemic praziquantel (PZQ) is the standard treatment for schistosomiasis and liver fluke infections (opisthorchiasis and clonorchiasis). The development of an optimal pediatric formulation and dose se

5. The relationship between harmful alcohol use and antiretroviral non-adherence in people accessing HIV treatment in Cape Town, South Africa: an... (Publications)

   The relationship between harmful alcohol use and antiretroviral non-adherence in people accessing HIV treatment in Cape Town, South Africa: an event-level analysis

   Relevance:

   Harmful alcohol consumption can significantly compromise adherence to antiretroviral therapy (ART). Prior research has identified aggregate relationships between alcohol use and ART non-adherence, lar

6. Effects of a partially supervised conditioning program in cystic fibrosis: an international multicenter, randomized controlled trial (ACTIVATE-CF) (Publications)

   Effects of a partially supervised conditioning program in cystic fibrosis: an international multicenter, randomized controlled trial (ACTIVATE-CF)

   Relevance:

   Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear. Objectives: To evaluate effects of a 12-month partially supervised PA intervention

7. Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of <em>Ace1</em> point mutations (Publications)

   Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of <em>Ace1</em> point mutations

   Relevance:

   Insecticide resistance in Anopheles mosquitoes is seriously threatening the success of insecticide-based malaria vector control. Surveillance of insecticide resistance in mosquito populations and iden

8. Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in... (Publications)

   Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

   Relevance:

   Buruli ulcer (BU) is a neglected tropical disease caused by subcutaneous infection with Mycobacterium ulcerans and its exotoxin mycolactone. BU displays coagulative necrosis and widespread fibrin depo

9. <em>Plasmodium falciparum</em> parasite prevalence in East Africa: updating data for malaria stratification (Publications)

   <em>Plasmodium falciparum</em> parasite prevalence in East Africa: updating data for malaria stratification

   Relevance:

   The High Burden High Impact (HBHI) strategy for malaria encourages countries to use multiple sources of available data to define the sub-national vulnerabilities to malaria risk, including parasite pr

10. Detection of asymptomatic malaria in Asian countries: a meta-analysis of diagnostic accuracy (Publications)

    Detection of asymptomatic malaria in Asian countries: a meta-analysis of diagnostic accuracy

    Relevance:

    Background: Achieving malaria elimination requires the targeting of the human reservoir of infection, including those patients with asymptomatic infection. The objective was to synthesise evidence on