Pharmacological effects of primaquine ureas and semicarbazides on the CNS in mice and antimalarial activity in vitro (Publications)
New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for CNS and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 ce
Transport-related measures to mitigate climate change in Basel, Switzerland: a health-effectiveness comparison study (Publications)
BACKGROUND: Local strategies to reduce green-house gases (GHG) imply changes of non-climatic exposure patterns. OBJECTIVE: To assess the health impacts of locally relevant transport-related climate ch
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a s
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were id
Outcomes mapping study for childhood vaccination communication: too few concepts were measured in too many ways (Publications)
OBJECTIVES: The objectives of this paper are: 1) to comprehensively catalogue outcomes measured in trials of childhood vaccination communication interventions; and 2) to analyse patterns and trends in
Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-ba
Ability of physicians to diagnose influenza and usefulness of a rapid influenza antigen test in febrile returning travelers: a randomized controlled... (Publications)
BACKGROUND: Fever is a frequent cause of medical consultation among returning travelers. The objectives of this study were to assess whether physicians were able to identify patients with influenza an
The effect of malaria control on <em>Plasmodium falciparum</em> in Africa between 2000 and 2015 (Publications)
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this control effort is vital t