Prodrugs of reverse fosmidomycin analogues (Publications)
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium falciparum. The drug has been u
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188... (Publications)
BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national he
Are well functioning civil registration and vital statistics systems associated with better health outcomes? (Publications)
In this Series paper, we examine whether well functioning civil registration and vital statistics (CRVS) systems are associated with improved population health outcomes. We present a conceptual model
Safety and immunogenicity of a candidate bioconjugate vaccine against <em>Shigella dysenteriae</em> type 1 administered to healthy adults: a single... (Publications)
BACKGROUND: Shigellae cause severe disease in endemic countries, especially in children. Several efficacy trials have been conducted with candidate vaccines against Shigellae, but the lack of protecti
Using health and demographic surveillance system (HDSS) data to analyse geographical distribution of socio-economic status: an experience from... (Publications)
Continuous monitoring in health and demographic surveillance sites (HDSS) allows for collection of longitudinal demographic data, health related, and socio-economic indicators of the site population.
Acute schistosomiasis: a risk underestimated by travelers and a diagnosis frequently missed by general practioners - a cluster analysis of 42... (Publications)
BACKGROUND: In 2011, a patient was admitted to our hospital with acute schistosomiasis after having returned from Madagascar and having bathed at the Lily waterfalls. On the basis of this patient's in
Regional differences of physical activity and sedentary behaviour in Swiss children are not explained by socio-demographics or the built environment (Publications)
OBJECTIVE: We evaluated whether regional differences in physical activity (PA) and sedentary behaviour (SB) existed along language boundaries within Switzerland and whether potential differences would
Maximizing microscopy as a diagnostic tool in peripheral health centres of BU endemic areas in Ghana (Publications)
BACKGROUND: Buruli ulcer (BU) disease, a skin condition caused by Mycobacterium ulcerans (M. ulcerans) is endemic in remote rural areas. Disease diagnosis on clinical basis alone can be misleading, re
Academic institutions and One Health: building capacity for transdisciplinary research approaches to address complex health issues at the... (Publications)
To improve health at the human, animal, and ecosystem interface, defined as One Health, training of researchers must transcend individual disciplines to develop a new process of collaboration. The tra
