<em>Plasmodium</em> sensitivity to artemisinins: magic bullets hit elusive targets (Publications)
Artemisinins are efficacious antimalarial drugs widely employed as first-line treatment in endemic countries under the form of combined therapies. Different molecular modes of action have been postula
Perimenstrual increase in bronchial hyperreactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort (Publications)
BACKGROUND: Studies on perimenstrual asthma are inconsistent, and different methodologies limit comparisons. OBJECTIVE: To investigate cyclic variations in bronchial hyperreactivity (BHR) to methachol
Seroprevalences and local variation of human and livestock brucellosis in two villages in Gharbia Governorate, Egypt (Publications)
This study aimed at assessing the epidemiology of brucellosis among both human and livestock populations in an endemic area in Egypt. A cross-sectional survey was conducted in two villages, where 616
Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments (Publications)
BACKGROUND: Most complex diseases are the result of interactions between polymorphisms in the genome and environmental exposures. OBJECTIVE: We sought to investigate the previously reported associatio
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone (Publications)
An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structur
Effectiveness of dog rabies vaccination programmes: comparison of owner-charged and free vaccination campaigns (Publications)
We investigated the percentage of dogs that could be vaccinated against rabies by conducting a pilot campaign in N'Djamena, Chad. Owners were charged US$4.13 per dog vaccinated, and 24% of all dogs in
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers) (Publications)
Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of i