The comparative antimalarial properties of weak base and neutral synthetic ozonides (Publications)
Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high antimalarial potency against Plasmodium
Chromosomal translocations t(4;14), t(11;14) and proliferation rate stratify patients with mature plasma cell myelomas into groups with different... (Publications)
Plasma cell myelomas (PMs) exhibit clinical and molecular heterogeneity. To date, morphology and immunohistochemistry on bone marrow trephines are of limited value to stratify patients into different
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants (Publications)
Background The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied
Microhabitat preferences of <em>Biomphalaria pfeifferi</em> and <em>Lymnaea natalensis</em> in a natural and a man-made habitat in southeastern... (Publications)
Schistosoma mansoni is an important human parasitic disease which is widespread throughout Africa. As Biomphalaria pfeifferi snails act as intermediate host, knowledge of their population ecology is a
Source apportionment of ambient PM2.5 at five spanish centres of the european community respiratory health survey (ECRHS II) (Publications)
Fine particulate matter (PM2.5) was sampled at 5 Spanish locations during the European Community Respiratory Health Survey II (ECRHS II). In an attempt to identify and quantify PM2.5 sources, source c
Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study (Publications)
STUDY OBJECTIVE: To determine whether increased exposure to particulate matter air pollution (PM), measured with personal, residential, or central site monitoring, was associated with pulmonary functi
Comparative study of the effects of artemether and artesunate on juvenile and adult<em> Schistosoma mansoni</em> in experimentally infected mice (Publications)
Artemether and artesunate, derivatives of the antimalarial artemisinin, also exhibit antischistosomal properties. There is a need to assess comparatively the activity of both compounds against differe
Caught in action: mechanistic insights into antibody-mediated inhibition of <em>Plasmodium merozoite</em> invasion (Publications)
Apical membrane antigen 1 (AMA1) plays an essential role in host cell invasion by apicomplexan parasites. A recent study by Collins et al. investigated the mode of action of an anti-AMA1 invasion-inhi