Membrane protein turnover by the m-AAA protease in mitochondria depends on the transmembrane domains of its subunits (Publications)
AAA proteases are membrane-bound ATP-dependent proteases that are present in eubacteria, mitochondria and chloroplasts and that can degrade membrane proteins. Recent evidence suggests dislocation of m
Evolution of two distinct phylogenetic lineages of the emerging human pathogen <em>Mycobacterium ulcerans</em> (Publications)
ABSTRACT: BACKGROUND: Comparative genomics has greatly improved our understanding of the evolution of pathogenic mycobacteria such as Mycobacterium tuberculosis. Here we have used data from a genome m
Optimized DNA preparation from mycobacteria (Publications)
Extraction of genomic DNA from mycobacteria requires special consideration because (i) many mycobacterial species exhibit extremely slow growth, and thus produce only small amounts of starting materia
Single nucleotide polymorphism typing of <em>Mycobacterium ulcerans</em> reveals focal transmission of Buruli ulcer in a highly endemic region of... (Publications)
Buruli ulcer (BU) is an emerging necrotizing disease of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. While proximity to stagnant or slow flowing water bodies is a risk factor for
Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to <em>Mycobacterium... (Publications)
Mycolactone is an immunosuppressive cytotoxin responsible for the clinical manifestation of Buruli ulcer in humans. It was believed to be confined to its etiologic agent, Mycobacterium ulcerans. Howev