Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase (Publications)
This paper describes the design, synthesis and evaluation of a series of 2,4-diaminoquinazolines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were designed by a gen
Malaria elimination: moving forward with spatial decision support systems (Publications)
Operational challenges facing contemporary malaria elimination have distinct geospatial elements including the need for high-resolution location-based surveillance, targeted prevention and response in
<em>In vivo</em> activity of aryl ozonides against <em>Schistosoma</em> species (Publications)
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Sc
Association between <em>Schistosoma mansoni </em>and hookworm infections among schoolchildren in Côte d'Ivoire (Publications)
Infections with Schistosoma mansoni and hookworms are widespread in sub-Saharan Africa and the burden of disease associated with both parasites is enormous. Although there is a large overlap in their
Identification of a synthetic peptide inducing cross-reactive antibodies binding to <em>Rhipicephalus (Boophilus) decoloratus</em>, <em>Rhipicephalus... (Publications)
The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vacc
Effect of school-based interventions on physical activity and fitness in children and adolescents: a review of reviews and systematic update (Publications)
Background School-based interventions are thought to be the most universally applicable and effective way to counteract low physical activity (PA) and fitness although there is controversy about the o
